间充质干细胞在宫腔粘连及其他子宫内膜损伤治疗方面的研究进展

Progress of research on mesenchymal stem cells in treatment of intrauterine adhesions and endometrial injury

宫腔粘连(IUA)多继发于反复刮宫或者宫腔内感染。主要表现为月经不规则、不孕、反复流产等。目前仍以宫腔镜下粘连分解术(TCRA)并辅以雌激素治疗为主要手段,术后可放置球囊支架、宫内节育器、透明质酸等。但重度宫腔粘连患者术后复发率高、生育功能经常规方法治疗后难以恢复。以往的研究已经证明干细胞能通过促进子宫内膜再生和修复来治疗宫腔粘连,但由于移植成活率低、定向诱导分化困难和干细胞成瘤性等问题,无法广泛应用于临床。本文就近年来利用间充质干细胞治疗子宫内膜损伤及宫腔粘连的文章作一综述,为宫腔粘连的治疗提供新的思路。

Intrauterine adhesion(IUA)is mainly secondary to repeated curettage or intrauterine infection.The main symptoms of IUA include irregular menstruation,infertility,repeated abortion and so on.At present,transcervical resection of adhesions(TCRA)combined with estrogen therapy is the main treatment.Balloon stents,IUDs and hyaluronic acid can be placed after surgery.However,the recurrence rate of severe intrauterine adhesions is still high,and the reproductive function is difficult to recover by conventional treatments.Previous studies have demonstrated that stem cells can help to treat intrauterine adhesions by promoting the regeneration and repair of endometrium.However,stem cells cannot be widely used clinically because of their low survival rate,difficulty of induced differentiation and stem cell tumorigenesis.This paper reviews the recent advances in using mesenchymal stem cells for the treatment of endometrial injury and intrauterine adhesions to provide new ideas for the treatment of intrauterine adhesions.