白芍总苷辅助治疗对过敏性紫癜患儿辅助性T细胞、高迁移率族蛋白1表达的影响

Effect of Total Glucosides of Paeony on Helper T cells and High Mobility Group-1 Protein in the Treatment of Pediatric Allergic Purpura

目的:探究白芍总苷辅助治疗对过敏性紫癜患儿辅助性T细胞、高迁移率族蛋白1表达的影响。方法:选取符合纳入标准的过敏性紫癜患儿78例随机分成两组,对照组(36例)采用西药治疗,观察组(36例)在对照组基础上应用白芍总苷辅助治疗。观察两组患儿辅助性T细胞(IL-7、IL-10以及TGF-β)、炎症因子(HMGB-1、IL-8、IL-14、IL-33)、疗效和复发率。结果:在辅助性T细胞指标方面比较,两组患儿经过治疗后IL-17水平显著下降(P <0. 05),而IL-10、TGF-β水平显著升高(P <0. 05);治疗后的组间比较,观察组IL-17水平显著低于对照组(t=2. 072,P <0. 05),而IL-10、TGF-β水平显著高于对照组(t=3. 295、3. 364,P <0. 05)。两组患者治疗后,HMGB-1及其他炎症因子均显著下降(均P <0. 05);治疗后的两组比较,观察组在各项炎症因子水平上显著低于对照组(t=4. 618、2. 618、3. 056、3. 049,P <0. 05)。观察组的有效率为86. 11%(31/36),显著高于对照组的63. 89%(23/36)(χ~2=4. 741,P <0. 05)。随访结束后,观察组总复发率为11. 11%(4/36),显著低于对照组的30. 56%(11/36)(χ~2=4. 126,P <0. 05)。结论:对过敏性紫癜患儿辅助性应用白芍总苷能够提高机体内辅助性T细胞的活性物质,清除高迁移率族蛋白1,清除患儿体内的炎症因子,提高有效率,降低复发率。

Objective: To explore the effect of total glucosides of paeony on helper T cells and high mobility group-1 protein in the treatment of pediatric allergic purpura. Methods: 78 children with allergic purpura were randomly divided into the control group(n=39) and the observation group(n=39). The control group was treated with western medication;on which basis, the observation group was also treated with total glucosides of paeony. Helper T cells(IL-7, IL-10, and TGF-β), inflammatory cytokines(HMGB-1, IL-8, IL-14, and IL-33), efficacy(cured, remarkably effective, effective, and invalid), as well as recurrence rate were observed in the two groups. Results: In terms of helper T cells, IL-17 level was decreased( t =3.295, 3.364, P<0.05), and the levels of IL-10 and TGF-β were increased( P<0.05) in the two groups after the treatment;of which the changes were more significant in the observation group than those in the control group( t =2.072, P<0.05). The levels of HMGB-1 and other inflammatory factors were significantly decreased after the treatment in the two groups( P<0.05);of which the observation group decreased more significantly than the control group( t =4.618, 2.618, 3.056, 3.049, P<0.05). In terms of the curative effect, it was 86.11%(31/36) in the observation group, which was significantly higher than 63.89%(23/36) in the control group(χ^2=4.741, P<0.05). In terms of the recurrence rate until the follow-up, it was 11.11%(4/36) in the observation group, which was greatly lower than 30.56%(11/36) in the control group(χ^2=4.126, P<0.05). Conclusion: The auxiliary application of total glucosides of paeony can increase the active substances of helper T cells, it can remove the high mobility group-1 protein and other inflammatory factors in the children's body in the treatment of allergic purpura. It can increase the curative rate and reduce the recurrence rate.