血必净联合乌司他丁对急性呼吸窘迫综合征患者肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平的影响

Effect of Xuebijing Combined with Ulinastatin on the Levels of Tumor Necrosis Factor-α(TNF-α)and Interleukin-6(IL-6)in Patients with Acute Respiratory Distress Syndrome

目的:探讨利用血必净联合乌司他丁对急性呼吸窘迫综合征患者肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平的影响。方法:选取在某院2015年6月～2017年7月确诊的急性呼吸窘迫综合征患者90例,随机分为对照组、只给予血必净治疗组和血必净联合乌司他丁治疗组,每组30例。对照组患者只给予常规治疗,血必净治疗组患者在常规治疗的基础上再给予血必净,血必净联合乌司他丁治疗组在常规治疗的基础上再给予血必净联合乌司他丁。分别在治疗前和治疗后7d抽取外周血测定3组患者的TNF-α、IL-6的水平。结果:治疗前血必净和联合治疗组急性呼吸窘迫综合征患者血清TNF-α和IL-6的水平与对照组比较,差异均无统计学意义(P>0.05);治疗7d后,血必净联合乌司他丁治疗组血清肿瘤坏死因子-α和白介素-6的水平与血必净治疗组和对照组相比明显降低,差异均有统计学意义(P<0.05)。结论:利用血必净联合乌司他丁治疗可减轻急性呼吸窘迫综合征患者的炎症反应。

Objective:To investigate the effect of Xuebijing combined with ulinastatin on the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in patients with acute respiratory distress syndrome.Methods:90 patients with acute respiratory distress syndrome diagnosed in a hospital from June 2015 to July 2017 were randomly divided into control group,Xuebijing group and Xuebijing combined with ulinastatin group,30 cases in each group.Patients were given only conventional treatment in the control group.Patients were given Xuebijing in the Xuebijing group,and Xuebijing combined with ulinastatin group were given Xuebijing and ulinastatin on the basis of routine treatment.The levels of TNF-αand IL-6 in three groups were measured respectively before and after treatment.Results:Before treatment,the serum levels of TNF-αand IL-6 in patients with acute respiratory distress syndrome treated with Xuebijing and combination therapy were not significantly different from those in control group(P>0.05).After 7 days of treatment,compared with the Xuebijing group and the control group,the levels of serum tumor necrosis TNF-αand IL-6 in the net combined ulinastatin group were significantly decreased(P<0.05).Conclusion:The use of Xuebijing combined with ulinastatin can reduce the inflammatory response in patients with acute respiratory distress syndrome.