溃疡性结肠炎的非手术治疗进展

Research progress in non-surgical treatment of ulcerative colitis

溃疡性结肠炎(UC)是一种病因尚不明确,累及直肠和结肠的慢性非特异性肠道炎性疾病。目前UC的常规治疗药物主要有氨基水杨酸、糖皮质激素和免疫抑制剂,当合并严重并发症及癌变时可行手术治疗。随着研究进一步深入,出现了新型治疗方式,主要包括沙利度胺、生物制剂、粪菌移植、选择性白细胞吸附疗法及干细胞疗法等。该文通过综述UC非手术治疗的研究现状,从而为临床上治疗UC提供一定的参考。

Ulcerative colitis(UC) is a chronic nonspecific inflammatory intestinal disease involved with the rectum and colon with an elusive etiology. Currently, the therapeutic drugs of UC mainly include amino salicylic acid, corticosteroids and immunosuppressor. Surgical intervention is considered in those UC patients with severe complications and canceration. Along with the research progression, novel therapeutic technologies of US emerge, such as thalidomide, biological agents, fecal microbiota transplantation, selective leukocytapheresis and stem cells, etc. In this article, the research progress in the non-surgical treatment of UC was summarized, aiming to provide reference for clinical treatment of UC.