吸烟与慢性牙周炎患者牙周组织炎症反应、牙槽骨吸收的相关性研究

Relationship of smoking with periodontal tissue inflammation and alveolar bone resorption in patients with chronic periodontitis

目的:研究吸烟与慢性牙周炎患者牙周组织炎症反应、牙槽骨吸收的相关性。方法:选择2015年3月～2017年3月期间在营口市中心医院诊断为牙周炎的患者,并根据吸烟史分为有吸烟史的牙周炎A组、无吸烟史的牙周炎B组,另取同期在营口市中心医院体检且无牙周炎病史、无吸烟史的志愿者作为对照组,采集龈沟液并测定炎症反应指标、牙槽骨吸收指标的含量。结果:牙周炎A组、牙周炎B组患者龈沟液中ICAM1、HMGB1、IL-17、YKL40、CXCL16、NTX、CTX、RANKL、MMP9、EA的含量显著高于对照组,PICP、PIIICP、OPG、Runx2的含量低于对照组;牙周炎A组患者龈沟液中ICAM1、HMGB1、IL-17、YKL40、CXCL16、NTX、CTX、RANKL、MMP9、EA的含量显著高于牙周炎B组,PICP、PIIICP、OPG、Runx2的含量低于牙周炎B组。差异均有统计学意义(P均<0.05)。结论:吸烟能够加重慢性牙周炎患者牙周组织的炎症反应、促进牙槽骨的吸收。

Objective: To study the relationship of smoking with periodontal tissue inflammation and alveolar bone resorption in patients with chronic periodontitis. Methods: The patients diagnosed with periodontitis in Yingkou Central Hospital between March 2015 and March 2017 were selected and divided into the periodontitis group A with smoking history and the periodontitis group B without smoking history; volunteers who received physical examination in the hospital during the same period and had no history of periodontitis or smoking were collected as the control group. The gingival crevicular fluid was collected to measure the contents of inflammation indexes and alveolar bone resorption indexes. Results: ICAM1, HMGB1, IL-17, YKL40, CXCL16, NTX, CTX, RANKL, MMP9 and EA contents in gingival crevicular fluid of periodontitis group A and periodontitis group B were significantly higher than those of control group while PICP, PIIICP, OPG and Runx2 contents were significantly lower than those of control group; ICAM1, HMGB1, IL-17, YKL40, CXCL16, NTX, CTX, RANKL, MMP9 and EA contents in gingival crevicular fluid of periodontitis group A were significantly higher than periodontitis group B while PICP, PIIICP, OPG and Runx2 contents were significantly lower than those of periodontitis group B. Conclusion: Smoking can aggravate the periodontal tissue inflammation and promote the alveolar bone resorption in patients with chronic periodontitis.