早期肠内营养支持对重症急性胰腺炎患者的疗效及对T淋巴细胞亚群的影响

Efficacy of early enteral nutrition support in treating patients with severe acute pancreatitis and its effect on T lymphocyte subsets

目的分析对重症急性胰腺炎患者实施早期肠内营养支持的应用效果。方法将我院收治的重症急性胰腺炎患者101例,随机分为对照组(50例)和研究组(51例),对照组采用早期肠外营养支持治疗,研究组则采用早期肠内营养支持治疗,对比两组治疗前后血清学指标、T淋巴细胞亚群及肠内营养相关指标。结果两组治疗前,肿瘤坏死因子-α、C反应蛋白、白细胞介素-6、CD_3^+、CD_4^+、CD_4^+/CD8^+、血清转铁蛋白、前白蛋白、白蛋白水平比较,P均>0.05;两组治疗后,肿瘤坏死因子-α、C反应蛋白、白细胞介素-6、CD_3^+、CD_4^+、CD_4^+/CD8^+、血清转铁蛋白、前白蛋白、白蛋白水平比较,P均<0.05;同组治疗前后,肿瘤坏死因子-α、C反应蛋白、白细胞介素-6、CD_3^+、CD_4^+、CD_4^+/CD8^+、血清转铁蛋白、前白蛋白、白蛋白水平比较,P均<0.05。结论早期肠内营养支持干预可减轻症急性胰腺炎患者体内的炎症反应,提高患者的免疫功能及营养状况。

Objective To analyze the application effect of early enteral nutrition support in patients with severe acute pancreatitis. Methods 101 patients with severe acute pancreatitis admitted to our hospital were randomly divided into control group (50 cases) and study group (51 cases). The control group received early parenteral nutrition support treatment, and the study group used early enteral nutrition support. Treatment, comparison of serum indicators, T lymphocyte subsets and indicators of enteral nutrition before and after treatment. Results Before treatment, tumor necrosis factor-α, C-reactive protein, interleukin-6, CD3^+、CD4^+、CD4^+/CD8^+, serum transferrin, prealbumin and albumin were compared, P>0.05; After treatment, tumor necrosis factor-α, C-reactive protein, interleukin-6, CD3^+、CD4^+、CD4^+/CD8^+, serum transferrin, prealbumin, albumin were compared, P<0.05; the same group treatment Before and after, the levels of tumor necrosis factor-α, Creactive protein, interleukin-6, CD3^+、CD4^+、CD4^+/CD8^+, serum transferrin, prealbumin and albumin were all P<0.05. Conclusion Early enteral nutrition support intervention can alleviate the inflammatory response in patients with acute pancreatitis and improve their immune function and nutritional status.