β-内酰胺类抗生素的药物不良反应

Adverse drug reactions of beta-lactam antibiotics

目的:探讨β-内酰胺类抗生素的药物不良反应(ADR),更好地指导临床用药。方法:收集发生的β-内酰胺类抗生素ADR 60例,对患者的年龄、性别、用药情况等资料进行汇总分析。结果:60例患者中累及皮肤系统36例(60.0%),其次消化系统6例(10.0%),过敏性休克4例(6.7%),心血管系统4例(6.7%),呼吸系统、血液系统、泌尿系统等占比较小。结论:β-内酰胺类抗生素在临床使用中引发的不良反应比较多,合理使用β-内酰胺类抗生素药物并对患者进行及时检测、观察,以减少ADR的发生。

Objective:To explore the adverse drug reactions of beta-lactam antibiotics and better guide clinical medication. Methods:60 cases of adverse drug reactions of beta-lactam antibiotics were collected, and the data of age,sex and drug use were summarized and analyzed.Results:Of the 60 patients,36 cases(60.0%)were involved in the skin system,followed by 6 cases(10.0%) of the digestive system,4 cases(6.7%)of anaphylactic shock,and 4 cases(6.7%)of the cardiovascular system,the respiratory system, blood system,respiratory system,urinary system and so on account for a small proportion.Conclusion:There are many adverse reactions caused by beta-lactam antibiotics in clinical use.Rational use of beta-lactam antibiotics and timely detection and observation of patients can reduce the incidence of ADR.