晚期结直肠癌患者接受FOLFOX方案治疗对免疫功能的影响

Effect of FOLFOX regimen on the immune function of patients with advanced colorectal cancer

目的:探讨晚期结直肠癌患者接受FOLFOX方案治疗对免疫功能的影响。方法:收治晚期结直肠癌患者30例作为试验组,同期体检健康人30例作为对照组。对照组不予治疗干预,试验组给予FOLFOX方案治疗,比较两组CD4^+FoxP3^+细胞数和外周血细胞数。结果:试验组化疗结束时CD4^+FoxP3^+细胞低于化疗前,差异有统计学意义(P<0.05)。试验组外周血中CD3^+、CD4^+、CD8^+、CD4^+/CD8^+细胞数明显低于对照组,差异有统计学意义(P<0.05)。结论:晚期结直肠癌患者接受FOLFOX方案治疗可以改善免疫抑制状态,但对宿主的抗肿瘤免疫反应造成微小损害。

Objective:To investigate the effect of FOLFOX regimen on the immune function of patients with advanced colorectal cancer.Methods:30 cases of patients with advanced colorectal cancer were as the experiment group and 30 cases of healthy people were as the control group.The control group did not receive treatment intervention,and the experiment group was given FOLFOX regimen,the number of CD4 + FoxP3 + cells and peripheral blood cells were compared between the two groups.Results:The CD4 + FoxP3+ cells at the end of chemotherapy in the experiment group were significantly lower than those before chemotherapy,and the difference was statistically significant (P<0.05).The number of CD3 +,CD4 +,CD8 +,CD4 +/CD8 + cells in peripheral blood of the experiment group was significantly lower than that of the control group,and the difference was statistically significant (P<0.05). Conclusion:FOLFOX regimen could improve the immunosuppressive status in patients with advanced colorectal cancer,but it could cause minor damage to the host's anti-tumor immune response.