尿RBP、NAG联合血清CysC检测在2型糖尿病早期肾损伤患者中的意义分析

Significance analysis of urine RBP and NAG combined with serum CysC detection in patients with early renal injury in type 2 diabetes mellitus

目的:探讨尿RBP、NAG联合血清CysC检测在2型糖尿病早期肾损伤患者中的意义。方法:收治2型糖尿病肾病患者60例作为甲组,单纯2型糖尿病患者60例作为乙组,健康体检者60例作为丙组。通过免疫比浊法检测3组尿RBP、NAG、血清CysC水平。结果:甲、乙组RBP、NAG、血清CysC水平均高于丙组,且甲组RBP、NAG、血清CysC水平高于乙组,差异有统计学意义(P<0.05)。3项联合检测阳性率高于单项检测阳性率,差异有统计学意义(P<0.05)。结论:尿RBP、NAG、血清CysC作为准确检测2型糖尿病早期肾损伤的指标,3项联合可显著提高综合敏感性。

Objective:To investigate the significance of urinary RBP and NAG combined with serum CysC in patients with early renal injury in type 2 diabetes mellitus.Methods:60 cases of patients with type 2 diabetic nephropathy were as group A,60 cases of patients with type 2 diabetes mellitus were as group B and 60 cases of healthy people were as group C,the RBP,NAG and CysC in urine of the three groups were detected by immunoturbidimetry.Results:The levels of RBP,NAG and CysC in group A and group B were higher than those in group C,and the levels of RBP,NAG and CysC in group A were higher than those in group B,and the difference was statistically significant (P<0.05).The positive rate of the three combined tests was higher than that of the single test,and the difference was statistically significant (P<0.05).Conclusion:Urinary RBP,NAG and serum CysC could be used as accurate indicators of early renal injury in type 2 diabetes mellitus,and the combination of these three indicators could improve the comprehensive sensitivity significantly.