摘要
慢性肝脏疾病最终可能进展为肝纤维化甚至肝硬化。遗传因素在慢性肝脏疾病进展为肝纤维化过程中发挥重要作用。为更好地了解遗传因素在肝纤维化发病机制中的作用,探求肝纤维化临床治疗的新靶点,本文总结了近年来与肝纤维化发病相关的遗传易感基因的研究进展,对全基因组关联分析发现的基因(PNPLA3、TM6SF2、MBOAT7、MERTK、PDGFA和IL28B)进行详细论述。
Many chronic liver diseases would progress to liver fibrosis or even liver cirrhosis eventually.Genetic factors play an important role in the progression of chronic liver diseases to liver fibrosis.In order to identify the role of genetic factors in the pathogenesis of liver fibrosis and explore new clinical therapeutic targets,we summarized and sorted out the latest research on genetic susceptibility genes related to the pathogenesis of liver fibrosis in recent years,especially the genes discovered by genome-wide association analysis,including the patatin-like phospholipase domain containing 3(PNPLA3),transmembrane 6 superfamily member 2(TM6SF2),membrane bound O-acyltransferase domain containing 7(MBOAT7),myeloid-epithelial-reproductive tyrosine kinase(MERTK),platelet-derived growth factor A(PDGFA)and interleukin 28B(IL28B).
作者
朱慧玲
刘守胜
徐月
廖宋龄
辛永宁
ZHU Hui-ling;LIU Shou-sheng;XU Yue;LIAO Song-ling;XIN Yong-ning(Dalian Medical University,Dalian 116044,Liaoning Province,China;Central Laboratories,Qingdao Municipal Hospital,Qingdao 266071,Shandong Province,China;Digestive Disease Key Laboratory of Qingdao,Qingdao 266071,Shandong Province,China;Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao 266011,Shandong Province,China;Department of Infectious Diseases,Qingdao Municipal Hospital,Qingdao 266011,Shandong Province,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2018年第4期33-37,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家自然科学基金面上项目(31770837)
青岛市市南区科技发展资金项目(2016-3-016-YY)
关键词
慢性肝脏疾病
肝纤维化
遗传易感性
Chronic liver diseases
Liver fibrosis
Genetic susceptibility
