基于加速康复外科理念的多模式镇痛在结肠、直肠肿瘤术后的应用

Application of multi-mode analgesia based on rapid recovery surgery concept after colorectal cancer surgery

目的探讨在加速康复外科(ERAS)理念指导下的多模式镇痛模式对结肠、直肠肿瘤术后应激反应、临床结局的影响。方法选取结肠、直肠肿瘤手术患者,根据术后镇痛方式分为常规镇痛组与多模式镇痛组,比较2组患者术后应激反应、术后胃肠功能恢复情况及住院结局的差异。结果 2组患者一般资料比较,差异无统计学意义(P> 0. 05)。与常规镇痛组比较,多模式镇痛组患者的术后白细胞和C反应蛋白显著降低,术后胃肠功能恢复显著提前,住院时间显著缩短,差异均有统计学意义(P <0. 05)。结论加速康复外科理念指导下的多模式镇痛可显著减轻结肠、直肠肿瘤术后患者的应激反应,并能有效促进术后肠功能恢复。

Objective To explore the effect of multi-mode analgesia based on rapid recovery surgery concept on postoperative stress response and clinical outcomes of colorectal cancer surgery.Methods Patients undergoing colorectal cancer surgery were divided into conventional analgesia group and multi-mode analgesia group according to the type of postoperative analgesia.The postoperative stress response,postoperative bowel function recovery and hospital outcome were compared between the two groups.Results There was no difference in the general statistical data between the two groups(P>0.05).Patients with multi-mode analgesia had a significant decrease in postoperative white blood cells and C-reactive protein,significantly improved postoperative bowel function recovery,and shorter hospital stays(P<0.05).Conclusions Multi-mode analgesia guided by the concept of rapid rehabilitation surgery can significantly reduce the stress response after colorectal cancer surgery,and effectively promote the recovery of postoperative bowel function.