胰岛素经鼻内给药对老年患者术后谵妄的预防作用

Preventive effect of intranasal insulin administration on postoperative delirium in elderly patients

胰岛素不仅可以调节体内外周和脑内能量代谢,而且是一种可调节外周和脑血流量的血管活性激素,已证明脑内胰岛素可以调节神经传递、学习和记忆,并且具有神经保护作用。目前,将胰岛素经鼻内给药作为一种无创方式有可能成为治疗神经认知功能障碍的潜在治疗选择,因此,胰岛素经鼻内给药增加中枢神经系统中胰岛素水平对预防老年患者术后谵妄的发生可能具有重要意义。

Insulin not only regulates energy metabolism in the body, but also is a vasoactive hormone that can regulate blood flow in brain and peripheral blood. It has been proved that insulin in the brain can regulate nerve transmission, learning and memory, and has neuroprotective effects. At present, intranasal administration of insulin as a non-invasive method may become a potential treatment option for neurocognitive impairment. Therefore, intranasal administration of insulin to increase insulin levels in the central nervous system may be of great significance in preventing postoperative delirium in elderly patients.