小儿骶尾部畸胎瘤预后不良的影响因素分析

Analysis of prognostic risk factors for children with sacrococcygeal teratoma

目的探讨影响小儿骶尾部畸胎瘤预后的危险因素。方法回顾性分析2006年1月至2015年12月由湖南省儿童医院收治的78例小儿骶尾部畸胎瘤患儿临床资料(包括诊断时年龄、性别、临床分型、肿瘤大小、肿瘤性状、血清AFP值、病理类型及术后并发症),单因素分析采用χ2检验,多因素分析采用Logistic回归。结果多因素Logistic发现影响小儿骶尾部畸胎瘤预后的危险因素为:病理类型(OR=17. 902,95%CI:7. 652～24. 362)、诊断年龄(OR=8. 601,95%CI:4. 321～13. 350)、临床分型(OR=7. 161,95%CI:3. 215～11. 856)、肿瘤性状(OR=5. 493,95%CI:1. 420～9. 325)。结论诊断年龄、临床分型、肿瘤性状及病理类型是影响小儿骶尾部畸胎瘤预后的影响因素。

Objective To explore the prognostic risk factors for children with sacrococcygeal teratoma (SCT). Methods The clinical data were analyzed for 78 SCT children from January 2006 to December 2015.And the relevant factors included gender,diagnostic age,clinical classification,tumor size,tumor traits,serum level of alpha fetoprotein (AFP),pathological type and postoperative complications.The postoperative recurrence and canceration of teratoma were followed up simultaneously.Then statistical analysis was made by SPSS for each prognostic factor. Results Pathological type ( OR =17.902,95% CI :7.652~24.362),diagnostic age ( OR =8.601,95% CI :4.321~13.350),clinical classification ( OR =7.161,95% CI :3.215~ 11.856 )and tumor trait( OR=5.493 ,95% Cl :1.420~9.325) were significantly associated with prognosis (P<0.05). Conclusion Diagnostic age,clinical classification,tumor trait and pathological type are prognostic risk factors for children with sacrococcygeal teratoma.