低剂量黄体酮注射液联合保胎无忧胶囊治疗先兆流产的临床效果

The efficacy of low-dose progesterone injection combined with Baotaiwuyou capsule for treating patients with threatened abortion

目的:探讨低剂量黄体酮注射液联合保胎无忧胶囊在先兆流产患者中的应用效果。方法:纳入2017年3月-2018年3月本院妇产科收治的先兆流产患者94例,根据随机数字表法分两组,对照组47例给予低剂量黄体酮肌肉注射治疗(20mg/d,1次/d);观察组47例在对照组治疗基础上给予保胎无忧胶囊治疗(4粒/次,3次/d);两组均用药2周后评价疗效,记录临床症状缓解时间,治疗前后下腹疼痛和腰酸的VAS评分、血清孕酮(P)、雌二醇(E2)、绒毛膜促性腺激素(β?hCG)水平及药物不良反应。结果:观察组治疗总有效率(95.7%)高于对照组(78.7%),阴道流血消失时间、下腹疼痛和腰酸缓解时间均较对照组显著缩短(P<0.05);两组治疗后的VAS评分与治疗前比较均显著降低,且观察组低于对照组(P<0.05);两组治疗后血清P、E2、β?hCG水平水平均显著上升,且观察组高于对照组(P<0.05);观察组不良反应发生率(8.5%)与对照组(10.6%)相当(P>0.05)。结论:低剂量黄体酮注射液联合保胎无忧胶囊治疗先兆流产疗效确切,可显著改善患者临床症状,降低疼痛程度,上调血清P、E2、β?hCG水平,用药安全。

Objective: To investigate the efficacy of low-dose progesterone injection combined with Baotaiwuyou capsule for treating patients with threatened abortion. Methods: 94 patients with threatened abortion admitted to the second affiliated hospital of Xi 'an medical college from March 2017 to March 2018 were included and were divided into two groups according to the random number table method. The 47 patients in the control group were given intramuscular injection of low-dose progesterone, 20mg/d, once a day, and 47 patients in observation group were given Baotaiwuyou capsule (4 capsules/time, 3 times per day) except intramuscular injection of low-dose progesterone. Efficacy of patients in both groups was evaluated after 2 weeks treatment. The time of clinical symptom remission, the abdominal pain and back pain VAS score, serum P, E 2, and β-hCG levels before and after treatment were recorded. The incidences of adverse reactions of patients in both groups were also observed. Results: The total effective rate of patients in observation group was 95.7%, which was significantly higher than that (78.7%) of patients in control group ( P < 0.05 ). The disappearance time of vaginal bleeding, relief time of lower abdominal pain and backache of patients in observation group were significant shorter than those of patients in control group ( P <0.05). The VAS scores of patients after treatment were significant lower than those of patients before treatment in both groups (P<0.05), but the VAS scores of patients in observation group was significant lower than that of patients in control group after treatment ( P <0.05). The levels of serum P, E 2, and β-hCG of patients increased significantly after treatment in both groups ( P < 0.05 ), but the levels of serum P, E 2, and β-hCG of patients in observation group were significant higher than those of patients in control group after treatment ( P <0.05). The incidence of adverse reactions of patients in observation group was 8.5%, which was equivalent to that (10.6%) of patients in control group ( P >0.05). Conclusion: Low-dose progesterone injection combined with Baotaiwuyin capsule has an exact therapeutic effectiveness for treating patients with threatened abortion. It can significantly improve the clinical symptoms, can reduce the pain level of patients, and can up-regulate the levels of serum P, E 2, and β-hCG, and it has good safey.