硫酸镁在前置胎盘期待疗法中的应用效果及对新生儿脐血血气水平的影响

Effect of magnesium sulfate for expectant treatment of pregnant women with placenta previa and its influence on umbilical cord blood gas level of newborn

目的:探讨硫酸镁在前置胎盘产妇期待疗法中的应用效果及对新生儿脐血血气水平的影响。方法:选取2011年1月—2017年1月本院收治的前置胎盘孕妇92例,采用随机数字表法分为观察组和对照组各46例,两组均给予止血芳酸、维生素K等基础治疗,观察组同时给予硫酸镁进行辅助治疗,对比两组的临床治疗效果、新生儿脐血血气相关指标。结果:观察组的阴道流血停止时间、期待疗法治疗时间、产后出血量均低于对照组(P<0.05),产前出血量两组比较无差异(P>0.05);观察组的延长孕周时间长于对照组,新生儿体质量、1min及5min Apgar评分均高于对照组(均P<0.05);观察组新生儿死亡率(4.5%)与对照组(10.9%)比较无差异(P>0.05),新生儿脐动脉血pH、氧分压(PaO2)、剩余碱(BE)水平高于对照组,脐动脉血PaCO2水平低于对照组(均P<0.05)。结论:硫酸镁在前置胎盘产妇期待疗法中具有较好的应用效果,能改善新生儿的血气水平。

Objective:To explore the effect of magnesium sulfate for expectant treatment of pregnant women with placenta previa,and to analyze its influence on umbilical cord blood gas level of newborn.Methods:92 pregnant women with placenta previa admitted to Wuzhou women and children hospital were selected from January 2011 to January2017,and were randomly divided into experimental group and control group(46 cases in each group).The women in control group were given basic therapies such as hemararic acid,vitamin K,and so on,and the women in experimental group were treated by magnesium sulfate except basic therapies.The clinical efficacy and umbilical cord blood gas related indicators of the two groups were compared.Results:The time of vaginal bleeding,expectant treatment and postpartum hemorrhage of women in experimental group were significant lower than those of women in control group(P<0.05).There was no significant different in the amount of antepartum bleeding of women between the two groups(P>0.05).The prolongation of gestation time of women in experimental group was significant longer than that of women in control group(P<0.05).The body weight,1 min and 5 min Apgar scores of the newborn in experimental group were significant higher than those of newborn in control group(P<0.05).The neonatal mortality rate of experimental group was 4.5%,which had no statistically significant different(P>0.05)when compared to that(10.9%)of control group.The umbilical artery blood pH,PaO2 and BE levels of newborn in experimental group were significant higher than those of newborn in control group(P<0.05).The PaCO2 level of the umbilical artery of newborn in experimental group was significant lower than that of newborn in control group(P<0.05).Conclusion:Magnesium sulfate has good clinical effect for expectant treatment of pregnant women with placenta previa,which can significantly improve the blood gas level of newborn.