检测sFlt-1、PIGF、25-羟基维生素D、D-二聚体诊断子痫前期价值

The value of levels of sFlt 1,PIGF,25 hydroxyvitamin D,and D dimer for diagnosising pregnant women with preeclampsia

目的:探讨sFlt-1、PIGF、25-羟基维生素D、D-二聚体检验在子痫前期诊断价值。方法:回顾性收集本院产前检查的540例孕妇作为研究对象,其中子痫前期30例(观察组),正常妊娠510例(对照组)。对研究对象进行sFlt-1、PIGF、25-羟基维生素D、D-二聚体检验,并分析各项指标对子痫前期的诊断敏效能。结果:观察组sFlt-1、D-二聚体水平均高于对照组,PIGF、25-羟基维生素D水平均低于对照组(P<0.05)。观察组中,轻度子痫前期亚孕妇的sFlt-1、D-二聚体水平均低于重度子痫前期孕妇,PIGF、25-羟基维生素D水平均高于重度子痫前期孕妇(P<0.05)。sFlt-1、PIGF、25-羟基维生素D、D-二聚体ROC曲线下面积均>0.8,对子痫前期均有较高的敏感性与特异性,4项指标联合检测对子痫前期的敏感性、特异性更高(88.9%、98.4%)(P<0.05)。结论:妊娠早期联合检测sFlt-1、PIGF、25-羟基维生素D、D-二聚体,对子痫前期有较高的诊断价值。

Objective:To investigate the value of levels of sFlt 1,PIGF,25 hydroxyvitamin D,and D dimer for diagnosising pregnant women with preeclampsia.Methods:The data of 540 pregnant women who had undergone prenatal examination in Nanjing Dachang hospital were retrospective analyzed,which included 30 pregnant women with preeclampsia(in observation group)and 510 normal pregnant women(in control group).The levels of sFlt 1,PIGF,25 hydroxyvitamin D and D dimer of pregnant women in both groups were detected,and the sensitivity and specificity of the levels of sFlt 1,PIGF,25 hydroxyvitamin D or D dimer for diagnosing preeclampsia were analyzed.Results:The levels of sFlt 1 and D dimer of pregnant women in observation group were significant higher than those of pregnant women in control group,and the levels of PIGF and 25 hydroxyvitamin D of pregnant women in observation group were significant lower than those of pregnant women in control group(P<0.05).In observation group,the sFlt 1 and Ddimer levels of pregnant women with mild preeclampsia were significant lower than those of pregnant women with severe preeclampsia,and the PIGF and 25 hydroxyvitamin D levels of pregnant women with mild preeclampsia were significant higher than those of pregnant women with severe preeclampsia(P<0.05).The area under the ROC curve of levels of sFlt 1,PIGF,25 hydroxyvitamin D,and D dimer are all>0.8,which had high sensitivity and specificity for diagnosing preeclampsia.The sFlt 1 and Ddimer levels combined with the PIGF and 25 hydroxyvitamin D levels for diagnosing preeclampsia had higher sensitivity(88.9%)and specificity(98.4%)(P<0.05).Conclusion:Combination of detection of levels of sFlt 1,PIGF,25 hydroxyvitamin D and D dimer of pregnant women during the first trimester pregnancy has high value for diagnosing preeclampsia.