高雄激素血症多囊卵巢综合征患者性激素和胰岛素水平分析

Analysis of detection of sex hormone and insulin levels of patients with PCOS and hyperandrogenemia

目的:探讨以高雄激素血症为特征的育龄期多囊卵巢综合征(PCOS)患者体内性激素及胰岛素水平的变化。方法:选择2011年9月-2014年8月本院收治的高雄激素血症PCOS患者200例为观察组,另选择同期本院健康妇女200例作为对照组。采用电化学发光法检测睾酮(T)、雌二醇(E2)、促黄体生成素(LH)、促卵泡刺激素(FSH)、孕酮(P)、空腹胰岛素(FINS)的含量,同时采用葡萄糖氧化酶法检测空腹血糖(FPG)的含量,通过稳态模式评估法计算胰岛素抵抗(HOMA-IR)。结果:观察组中81%的PCOS患者患有高胰岛素血症,85.4%患有胰岛素抵抗,42%患有高黄体生成素血症,PCOS患者血清T、E2、LH、LH/FSH、FINS和HOMA-IR高于对照组(P<0.05)。结论:以高雄激素血症为特征的PCOS患者存在高胰岛素血症、胰岛素抵抗、高黄体生成素血症等激素紊乱征象,故及时监测患者激素水平,并给予针对性治疗,改善患者临床症状及内分泌环境,以期减少相关疾病的发生。

Objective:To investigate the changes of sex hormone and insulin levels of childbearing age women with PCOS and hyperandrogenemia,and to provide evidences for clinical diagnosis and treatment of women with PCOS who had menstrual disorder,infertility,or other symptoms.Methods:200 women with PCOS and hyperandrogenemia in Tianjin central obstetrics and gynecology hospital from September 2011 to August 2014 were included in PCOS group,and 200 healthy women were recruited in control group during the same period.The serum levels of testerone(T),estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),Pesterone(P),fasting insulin(FINS)of all included women were detected by electrochemiluminescence immunoassay,and fasting plasma glucose(FPG)level was measured by glucose-oxidase method.The insulin resistance was calculated through the homeostasis model assessment(HOMA-IR).Results:Among 200 women in PCOS group,81% women had hyperinsulinemia,85.4%women had insulin resistance,and 42% women had hyperluteinemia.Compared with those of women in control group,the serum levels of T,E2,LH,LH/FSH radio,FINS and HOMA-IR of women in PCOS group were significant higher(P<0.05).Conclusion:Women with PCOS and hyperandrogenemia have hormonal disorders,such as hyperinsulinemia,insulin resistance,and hyperluteinemia.In order to reduce the pain of patients and to decrease the incidence of disease,it is important to monitor hormone levels,and to treat for alleviating the clinical symptoms and improving patients’ endocrine environment.