不明原因复发性流产的免疫治疗策略

Immunotherapy for unexplained recurrent spontaneous abortion

复发性流产的病因多种多样,但仍有约50%的复发性流产患者病因不明,称为不明原因复发性流产(URSA),其治疗方法多样,有的存在争议。URSA被认为与母胎免疫耐受失衡有关,近年来关于URSA免疫失衡和治疗的研究是生殖领域的一大热点。本文对国内外URSA的免疫治疗方法进行综述,旨在为临床治疗提供参考。

Various causes have been found to contribute to the pathogenesis of recurrent spontaneous abortion(RSA).Still about 50% of the RSA cases have no known etiology and are considered as unexplained recurrent spontaneous abortion(URSA).Though may treatments have been for URSA,but some of them remain controversial.URSA has been assumed to be caused by a defect in maternal immunological tolerance to the fetus,so researches on the immune disturbance and immunomodulatory treatments for URSA have become a hot topic in the field of reproduction recently.Evaluation of the therapeutic strategies for URSA in this review aims at providing evidence for facilitating clinical therapy.