IL-21/IL-21R信号在IBD病变形成机制中作用的研究进展

Progress in Studies on the Roles of IL-21/IL-21R Signaling in the Pathogenesis of Inflammatory Bowel Disease

炎症性肠病(Inflammatory bowel disease,IBD)的发病机制至今尚不明确,普遍认为是由肠黏膜免疫调节异常、持续性肠道感染、肠黏膜屏障缺损、遗传和环境等多种因素相互作用导致的。近年来,研究发现IBD患者血清中IL-21水平异常升高,提示IL-21/IL-21R信号可能在IBD的病变形成中发挥重要作用。IL-21是一种重要的具有多重生物学功能的细胞因子,通过对CD4+T细胞、CD8+T细胞、Th17细胞、B细胞、巨噬细胞、树突状细胞等多种细胞产生影响,从而参与IBD的发生发展。本文就IL-21/IL-21R信号在炎症性肠病发病机制中的研究进展进行综述。

Inflammatory bowel disease is a kind of chronic intestinal inflammatory disease, its etiology and pathogenesis are not clear, generally considered by the interactions of many factors such as intestinal mucosal immune regulation, persistent intestinal infection, intestinal mucosal barrier defect, heredity and environment. In recent years, studies have found that the level of IL-21 in the serum of patients with IBD is abnormally elevated, suggesting that IL-21/IL-21R signaling may play an important role in IBD. IL-21, an important cytokine with multiple biological functions, participates in the development of IBD by influencing many kinds of cells including CD4^+T cells, CD8^+T cells, Th17 cells, B cells, macrophages, dendritic cells. In this study, we will review the development of IL-21/IL-21R signaling in the pathogenesis of inflammatory bowel disease.