氨酚氢可酮与曲马多治疗急诊科患者中重度疼痛的效果比较

Comparison of the effect of hydrocodone-acetaminophen and tramadol in the treatment of patients with moderate and severe pain in the department of emergency

目的比较氨酚氢可酮与曲马多治疗急诊科患者中重度疼痛的效果。方法选取2016年2月到2017年2月河南中医药大学第三附属医院急诊科105例中重度疼痛患者,按随机数表法分为对照组(52例)和观察组(53例)。对照组患者口服曲马多片1片/次,3次/d。观察组患者口服氨酚氢可酮1片/次,3次/d。采用视觉模拟评分(VAS)比较治疗前和治疗5 d后两组患者的疼痛强度。比较两组患者满意度、医生对两组患者的治疗满意度和治疗期间不良反应情况。结果治疗后,两组VAS评分较治疗前降低,观察组VAS评分低于对照组,差异有统计学意义(P <0. 05)。观察组患者满意度、医生满意度、不良反应发生率与对照组比较,差异无统计学意义(P> 0. 05)。不良反应发生后停药,均未出现后遗症。结论氨酚氢可酮治疗急诊科中重度疼痛效果显著,镇痛效果优于曲马多。

Objective To compare the effect of hydrocodone-acetaminophen and tramadol in the treatment of patients with moderate-severe pain in the department of emergency. Methods A total of 105 patients with moderate and severe pain in the department of emergency in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from February of 2016 to February of 2017 were selected. They were divided into two groups by the random number table method, 52 cases in control group and 53 cases in observation group. The patients in control group were received tramadol tablet, one pill for each time and three times a day. The patients in observation group were given hydrocodone-acetaminophen, one pill for each time and three times a day. Visual analogue score (VAS) was used to compare the pain intensity of the two groups before and after 5 days of treatment. The satisfaction of patients in two groups, the satisfaction of doctors to the effect of treatment in two groups and the adverse reaction during treatment were compared. Results After treatment, the VAS scores of both groups were lower than that of before treatment and the VAS score in observation group was lower than that in control group, and the differences were statistically significant (P <0.05 ). There were no statistically significant differences in satisfaction of patients, satisfaction of doctors and the rate of adverse reaction in two groups (P >0.05 ). There was no sequelae after discontinuation of adverse reactions. Conclusion Hydrocodone-acetaminophen is effective in the treatment of moderate-severe pain in the department of emergency, and the analgesic effect is superior than tramadol.