大株红景天注射液对急性脑梗死患者脑代谢产物影响的磁共振波谱定量分析

Quantitative Analysis of the Effect of Sofren Injection on Brain Metabolites in Patients with Acute Cerebral Infarction by Magnetic Resonance Spectroscopy

目的观察大株红景天注射液对急性脑梗死患者脑代谢产物的影响,并采用磁共振波谱(MRS)定量分析进行评价。方法选取本院就诊的60例急性脑梗死患者,按照随机数字表法分为观察组和对照组,每组30例。在常规治疗基础上,对照组采用丹参注射液治疗,观察组采用大株红景天注射液治疗。治疗2周后,采用MRS定量分析检测患者脑梗死周围区组织代谢物N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)及乳酸(Lac)的含量,计算Cho/Cr、NAA/Cr和Lac/Cr值;检测血浆同型半胱氨酸(Hcy)、血管性假血友病因子(vWF)和α颗粒膜蛋白-140(GMP-140)等血栓相关因子水平。结果治疗前,2组患者各项指标比较差异无统计学意义(P>0.05)。治疗后,2组者NAA/Cr值较治疗前明显升高(P<0.05),2组Cho/Cr和Lac/Cr值较治疗前明显降低(P<0.05),观察组Cho/Cr、NAA/Cr和Lac/Cr值改变程度明显大于对照组(P<0.05)。2组患者治疗后Hcy、vWF和GMP-140血栓相关因子水平均较治疗前降低(P<0.05),且观察组降低程度大于对照组(P<0.05)。结论采用大株红景天注射液治疗急性脑梗死,能够改善梗死周围区脑细胞代谢,保护神经细胞,挽救缺血半暗带,降低血栓相关因子水平。

Objective To observe the effect of sofren injection on brain metabolites in patients with acute cerebral infarction,and to evaluate the therapeutic effect by quantitative analysis of magnetic resonance spectroscopy(MRS).Methods Sixty patients with acute cerebral infarction were randomly divided into observation group and control group,with 30 cases in each group.On the basis of routine treatment,the control group was treated with salvia miltiorrhiza injection,and the observation group with sofren injection.After 2 weeks of treatment,the contents of N-acetylaspartate(NAA),choline(Cho),creatine(Cr)and lactate(Lac)in the tissue around cerebral infarction were detected quantitatively by MRS,and the values of Cho/Cr,NAA/Cr and Lac/Cr were calculated.Plasma homocysteine(Hcy),von Willebrand factor(vWF)and α-granule membrane protein 140(GMP-140)were measured in both groups.Results There was no significant difference between the two groups before treatment(P>0.05).The NAA/Cr value of the two groups after treatment was significantly higher than that before treatment(P<0.05).The values of Cho/Cr and Lac/Cr in the two groups were significantly lower than those before treatment(P<0.05).The changes of Cho/Cr,NAA/Cr and Lac/Cr in the observation group were significantly improved than those in the control group(P<0.05).The levels of thrombus related factors Hcy,vWF and GMP-140 in the two groups were lower than those before treatment(P<0.05),and the degree of decrease in the observation group was higher than that in the control group(P<0.05).Conclusion The treatment of acute cerebral infarction with sofren injection can improve the metabolism of brain cells,protect nerve cells,save ischemic penumbra and decrease the level of thrombus related factors.