氧化应激损伤与口腔疾病相关性的研究进展

Research progress on the association between oxidative stress injury and certain oral diseases

氧化应激指由于细胞内源性抗氧化系统不能有效清除堆积在体内的大量自由基,导致机体内氧化和抗氧化系统处于失衡的一种状态,其参与各种疾病的发生、发展。口腔颌面部组织在各种内、外源性因素的刺激下,可引发氧化应激并导致相关组织损伤。本文就各种外周刺激引发口腔颌面部氧化应激损伤及其与口腔疾病(包括颞下颌关节紊乱病、咀嚼肌疾病、牙周病、口腔癌及癌前病变)相关性的研究进行综述,从氧化应激角度为相关口腔颌面部疾病的发病机制研究、诊断及治疗提供新思路。

Oxidative stress is a state in which oxidation exceeds the antioxidant systems when the endogenous antioxidant system cannot effectively remove the large amount of free radicals accumulated in the body.It participates in the development of various diseases.The oral cavity is usually attacked by multiple endogenous or exogenous stimulations,which can lead to stress injury.This article reviews the research progress of oxidative stress in oral and maxillofacial regions induced by various peripheral stimuli and its correlation with related diseases,including temporomandibular disorders,masticatory muscle diseases,periodontal diseases,oral cancer and precancerous lesions.It also provides a new idea for the etiologic investigation,diagnosis and treatment of oral diseases from the perspective of oxidative stress.Moreover,it provides an update of the literature concerning the association of oxidative stress with pathological conditions related to oral cavity,focusing on the diagnostic and therapeutic importance of the tests based on saliva specimens in a preventive perspective.