高血压合并高脂血症患者炎性反应及血管内皮功能指标的表达分析

The expression of inflammatory response in patients with hypertension and hyperlipidemia

目的观察高血压合并高脂血症患者炎性反应及血管内皮功能等指标的表达。方法选择2016年10月至2017年12月该院住院的高血压合并高脂血症患者200例(A组),单纯高血压患者50例(B组),单纯高脂血症患者50例(C组),健康体检者50例(D组),观察4组研究对象超敏C反应蛋白(hs-CRP)、血流介导的血管舒张反应(FMD)、硝酸甘油介导的血管舒张反应(NMD)、脉搏波转导速度(PWV)、总胆固醇(CHOL)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血糖(GLU)、肌酐(CR)、丙氨酸氨基转移酶(ALT)、同型半胱氨酸(Hcy)、平均动脉压(MAP)的表达。结果 4组研究对象GLU、ALT、CR比较,差异无统计学意义(P>0.05)。与D组比较,A、B、C 3组患者hs-CRP、PWV、Hcy明显升高(P<0.05),FMD、NMD明显降低(P<0.05),A组患者CHOL、LDL、TG与C组差异无统计学意义(P>0.05),较B、D组明显升高(P<0.05);A组患者MAP与B组差异无统计学意义(P>0.05),较C、D组明显升高(P<0.05);B组与C组在hs-CRP、PWV、Hcy、FMD、NMD等方面比较,差异无统计学意义(P>0.05);A组患者hs-CRP、Hcy、PWV较B、C组明显升高(P<0.05),FMD、NMD则明显降低(P<0.05)。结论高血压或高脂血症患者炎性反应较健康者严重,血管内皮功能较差,且动脉僵硬程度明显;高血压合并高脂血症患者比单纯高血压及单纯高脂血症患者炎性反应更严重,血管内皮功能更差,动脉僵硬度更加明显,发生心脑血管事件的风险更大,更加值得临床重视。

Objective To observe the expression of inflammatory response and vascular endothelial function in patients with hypertension and hyperlipidemia.Methods A total of 350 research objects were included in this research,they were divided into 4 groups,group A included 200 hypertension and hyperlipidemia patients;group B included 50 hypertension patients;group C included 50 hyperlipidemia patients;group D included 50 normal physical examinations.All the subjects were measured high sensitivity C reactive protein(hs-CRP),flow-mediated dilatation(FMD),nitroglycerin-mediated dilatation(NMD),pulse wave velocity(PWV),total cholesterol(CHOL),triglyceride(TG),Low density lipoprotein cholesterol(LDL),glucose(GLU),creatinine(CR),alanine aminotransferase(ALT),homocysteine(Hcy)and mean arterial pressure(MAP).Results There was no difference of GLU,ALT,CR between the four groups(P>0.05).The levels of hs-CRP,PWV and Hcy were lower and the levels of FMD,NMD were ligher in group D,compared with the other three groups(P<0.05);The levels of CHOL,LDL and TG in group A had no difference with Group C(P>0.05),but ligher than group B and group D(P<0.05).The level of MAP in group A had no difference with Group B(P>0.05),but was ligher than group C and group D(P<0.05).There was no difference of hs-CRP,PWV,Hcy,FMD,NMD in group B and group C(P>0.05);The levels of hs-CRP,Hcy and PWV in group A were higher than group B and group C,but the levels of FMD and NMD were lower than group B and group C(P<0.05).Conclusion Compared with the normal physical examinations,hypertension patients and hyperlipidemia patients have severe inflammatory response,vascular endothelial function and PWV;And hypertension and hyperlipidemia patients are more serious than hypertension patients and hyperlipidemia patients,maybe they had greater risk of cardiovascular events,so these people were more worthy of attention.