摘要
目的探讨重庆大学城地区人群17种人乳头瘤病毒(HPV)亚型感染的分布及与宫颈病变的相关性。方法对1 200例18~78岁的女性进行HPV分型检测,231例女性同时进行超薄液基细胞学检测(TCT)和HPV分型检测,对检测结果进行统计学分析。结果 HPV检测总阳性感染率为16.91%,其中低危型感染率为1.08%,高危型感染率为15.83%。高危型HPV感染中单一型感染126例,感染率为10.50%;多重感染以双重感染为主,感染率为5.33%。该地区最常见的高危亚型为HPV52、16、18、58,这4种亚型单一感染率占高危亚型单一感染率的62.70%。该地区HPV感染的主要年龄段为18~55岁,低危型HPV感染在各年龄段差异无统计学意义(P>0.05)。宫颈病变者高危HPV感染率为77.78%,显著高于无宫颈病变者的3.29%,差异有统计学意义(P<0.05)。结论重庆大学城地区女性宫颈HPV感染主要为单一感染,高危型感染以HPV52、16、18、58为主。该地区宫颈病变者高危型HPV感染率较高,应加强高危型HPV感染的健康宣教,重视病变前的筛查。
Objective To assess the infection status of human papillomavirus(HPV)in women in Chongqing University Town,and to investigate the relations between cervical lesions and HPV subtypes involved.Methods We analyzed the examination results of 1 200 women who received the HPV genotyping test in University Town Hospital of Chongqing Medical University from January 2017 to January 2018,and statistically analyzed the infection status of different genotypes of HPV.Among them,231 patients received thinprep cytologic test(TCT)examination.The relationship between cervical lesions and HPV infection was analyzed.Results The overall HPV infection rate was 16.91%,the overall infection rate of low-risk HPV was 1.08%and the overall infection rate of high-risk HPV was 15.83%.Among the patients infected with HPV,the rate of single high-risk HPV infection was 10.50%,the rate of multiple HPV infections was 5.33%.In the high-risk HPV infection,the four subtypes of the highest infection rate were HPV52,16,18 and 58.The patients in 18-55 year group had a high rate of HPV infection.The TCT results indicated that the rate of high-risk HPV infection was relatively higher in women with cervical lesions.Conclusion HPV infection is characterized by a high infection rate of single high-risk HPV infection in Chongqing University Town.The infection distributions of HPV subtypes are mainly HPV52,16,18 and 58,which is different from those of other regions in China.The rate of high-risk HPV infection in women with cervical lesions is relatively higher in Chongqing University Town.
作者
阿达莱提.卡米力
王晓亮
李俊龙
李文明
赵钰玫
封雪
薛建江
ADALAITI Kamili;WANG Xiaoliang;LI Junlong;LI Wenming;ZHAO Yumei;FENG Xue;XUE Jianjiang(Department of Clinical Laboratory,University Town Hospital of ChongqingMedical University,Chongqing 401331,China)
出处
《检验医学与临床》
CAS
2019年第1期41-44,共4页
Laboratory Medicine and Clinic