噻托溴铵不同给药方式用于治疗哮喘合并慢性阻塞性肺疾病的价值分析

Value of Different Administration Modes of Tiotropium Bromide in the Treatment of Asthma with Chronic Obstructive Pulmonary Disease

目的探讨噻托溴铵不同给药方式用于治疗哮喘合并慢性阻塞性肺疾病的应用效果。方法选取蓬莱市中医医院呼吸科和蓬莱市人民医院2017年4月—2018年5月期间收治的哮喘合并慢性阻塞性肺疾病患者96例为研究对象,随机分为3组,每组32例,对照组应用安慰剂,Ⅰ组应用2.5μg噻托溴铵,Ⅱ组应用5.0μg噻托溴铵,对比3组治疗情况。结果对照组中的FEV_1(0～24 h)峰值、FEV_1ACU0～24 h、FEV_1谷值为(341.23±10.25)、(96.55±9.86)、(137.84±9.52),Ⅰ组中的FEV_1(0～24 h)峰值、FEV_1ACU0～24 h、FEV_1谷值为(473.54±10.23)、(242.54±12.32)、(265.42±12.35),Ⅱ组中的FEV_1(0～24 h)峰值、FEV_1ACU0～24 h、FEV_1谷值为(473.64±10.42)、(243.12±12.24)、(264.85±12.46),Ⅰ组和Ⅱ组组间比较,差异无统计学意义(P>0.05);数值高于对照组,差异有统计学意义(P<0.05);3组的总有效率为65.63%、90.63%、87.50%,Ⅰ组和Ⅱ组组间比较,差异无统计学意义(P>0.05);数值高于对照组,差异有统计学意义(P<0.05)。结论噻托溴铵不同给药方式用于治疗哮喘合并慢性阻塞性肺疾病的应用效果均非常显著,改善了肺功能,提高了治疗效果,值得应用。

Objective To investigate the effect of different administration modes of tiotropium bromide on the treatment of asthma with chronic obstructive pulmonary disease. Methods A total of 96 patients with asthma and chronic obstructive pulmonary disease admit-ted to the Department of Respiratory Medicine of Penglai City Hospital of Traditional Chinese Medicine and Penglai People’s Hospital from April 2017 to May 2018 were randomly divided into three groups, 32 cases in each group. In the control group, placebo was used. In group Ⅰ, 2.5 μg of tiotropium bromide was used, and in group Ⅱ, 5.0 μg of tiotropium bromide was used to compare the three groups. Results FEV1(0-24 h) peak, FEV1 ACU0-24 h, FEV1 trough(341.23±10.25),(96.55±9.86),(137.84±9.52) in the control group,FEV1(0-24 h) in group I Peak value, FEV1 ACU0-24 h, FEV1 valley value(473.54±10.23),(242.54±12.32),(265.42±12.35), FEV1(0~24 h) peak in group Ⅱ, FEV1 ACU0-24 h, FEV1 valley value(473.64±10.42),(243.12±12.24),(264.85±12.46), the comparison between group Ⅰ and group Ⅱ was statistically insignificant(P>0.05); the value was higher than the control group, statistically significant(P<0.05) The total effective rate of the three groups was 65.63%, 90.63%, and 87.50%. There was no significant difference between the Ⅰ group and the Ⅱ group(P>0.05). The value was higher than the control group and statistically significant(P<0.05). Conclusion The different administration modes of tiotropium bromide are effective in the treatment of asthma with chronic obstructive pulmonary disease. It improves lung function and improves the therapeutic effect, which is worthy of application.