慢性肾脏病病人胃蛋白酶原Ⅰ、Ⅱ检测的意义

Significance of pepsinogenⅠand Ⅱ in patients with chronic kidney disease

目的探讨慢性肾脏病(CKD)病人蛋白酶原Ⅰ、Ⅱ检测结果对肾功能减退程度评估的价值。方法 2015年10月至2016年3月铜陵市人民医院收治的117例慢性肾脏病病人,根据肾功能减退程度分四组;对照组选取84例健康者。以酶联免疫方法检测各组样本的胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平,肌氨酸氧化酶法检测血肌酐(SCr)水平,做对比分析。结果慢性肾脏病各组病人的PGⅠ水平(μg/L)(251. 62±96. 36、308. 58±101. 89、379. 54±117. 09、401. 59±115. 42)、PGⅡ水平(μg/L)(25. 85±16. 17、25. 81±15. 79、23. 52±15. 04、31. 31±21. 57)均明显高于对照组(P <0. 05);随着肾功能减退程度的增加,PGⅠ的水平逐渐增高,PGⅠ与SCr呈明显正相关性(r=0. 618 0,P <0. 05); CKD各组之间PGⅡ水平的差异无统计学意义(P> 0. 05),PGⅡ与SCr呈正相关性(r=0. 205 1,P> 0. 05)。结论胃功能指标PGⅠ、PGⅡ的检测结果有助于慢性肾脏病肾功能损伤程度的监测和评价,特别是在肾功能损伤的早期阶段。

Objective To investigate the value of the detection results of the PepsinogenⅠandⅡin the evaluation of renal function in the patients with chronic kidney disease(CKD).Methods 117 cases of patients with chronic kidney disease were divided into 4 groups according to the degree of impairment of renal function 84 healthy subjects were also selected as control group.The ELISA was applied to measure the original 1(PGⅠ),pepsinogenⅡ(PGⅡ)in each sample,and the serum creatinine(SCr)level was tested by Muscle ammonia oxidase method,which were analyzed by SPSS.Results The results of PGⅠlevels(μg/L)(251.62±96.36,308.58±101.89,379.54±117.09,401.59±115.42)and PGⅡlevels(μg/L)(25.85±16.17,25.81±15.79,23.52±15.04,31.31±21.57)in patients with chronic kidney disease groupⅡwere significantly higher than the control group(P<0.05).With the increase of the degree of renal dysfunction,PGⅠlevels gradually increased.PGⅠwas significantly correlated with SCr(r=0.618 0,P<0.05).There was no significant difference in the level of PGⅡof each groups of CKD(P>0.05).PGⅡis positively related to SCr(r=0.205 1,P>0.05).Conclusion The results of PG and PGⅡare helpful to the monitoring and evaluation of renal function damage in chronic kidney disease,especially in the early stage of renal injury.