中西医结合治疗对腹型过敏性紫癜病人的疗效及血清免疫学指标的影响

Effect of combined treatment of traditional Chinese medicine and Western medicine on patients with abdominal allergic purpura

目的探究腹型过敏性紫癜患儿采用中西医结合治疗的疗效及对患儿血清免疫学指标的影响。方法选取黄冈市中心医院收治的120例腹型过敏性紫癜患儿,按照随机数字表法分为对照组和观察组,每组60例,对照组给予其泼尼松、氢化可的松、甲氰米胍及止血、护胃等常规西药治疗,观察组在此基础上给予半夏泻心汤加减辩证治疗,对比分析两组患儿治疗效果。结果观察组患儿总有效率(96. 67%)明显高于对照组患儿(83. 33%),差异有统计学意义(P <0. 05)。观察组治疗后患儿的补体C3(1. 47±0. 45) g/L、Ig A水平(2. 78±0. 54) g/L明显优于对照组患儿(2. 87±0. 64) g/L、(3. 11±0. 69) g/L,差异有统计学意义(P <0. 05)。观察组治疗后患儿Ig M(1. 35±0. 23) g/L、Ig G(9. 12±1. 21) g/L、IL-2(21. 43±4. 58) ng/L、IL-4(13. 42±3. 37) ng/L免疫学指标水平明显优于对照组患儿Ig M(2. 43±0. 75) g/L、Ig G(10. 32±1. 54) g/L、IL-2(18. 56±3. 12) ng/L、IL-4(17. 33±4. 87) ng/L(P <0. 05)。结论腹型过敏性紫癜患儿采用中西医结合治疗的疗效显著,促进患儿免疫血指标恢复,改善免疫功能。

Objective To explore the efficacy of integrated Chinese and Western medicine in children with abdominal allergic purpura and its effect on serum immunological indicators in children.Methods 120 children with abdominal allergic purpura admitted to Huanggang Central Hospital were selected.According to the digital table method,they were randomly divided into the control group and the observation group,with 60 children in each group.The control group was given conventional western medicine treatment such as prednisone,hydrocortisone,cyanoguanidine and hemostasis and stomach protection.On the basis of this,the observation group gave Banxia Xiexin Decoction plus and minus dialectical treatment.The treatment effects of the two groups were compared.Results The total effective rate of the observation group(96.67%)was significantly higher than that of the control group(83.33%),and the difference was statistically significant(P<0.05).The complement C3(1.47±0.45)g/L and IgA level(2.78±0.54)g/L in the observation group were significantly better than those in the control group(2.87±0.64)g/L,(3.11±0.69)g/L.The difference was statistically significant(P<0.05).The level of IgM(1.35±0.23)g/L,IgG(9.12±1.21)g/L,IL-2(21.43±4.58)ng/L,IL-4(13.42±3.37)ng/L in the observation group were significantly improved than that of the control group,IgM(2.43±0.75)g/L,IgG(10.32±1.54)g/L,IL-2(18.56±3.12)ng/L,IL-4(17.33±4.87)ng/L(P<0.05).Conclusion Children with abdominal allergic purpura are treated with integrated Chinese and Western medicine,which can promote the recovery of immune blood index and improve immune function.