摘要
A new photoprotective system based on encapsulating UVA (butyl methoxydibenzoylmethane, BMBM) and UVB (octyl methoxycinnamate, OMC) filters into nanostructured lipid carriers (NLC) has been prepared to develop cosmetic formulations with effective UV protection. BMBM/OMC-loaded NLC was prepared by ultrasonication-homogenisation, and analysed by particle size, zeta potential (ZP), encapsulation efficiency (EE), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Moreover, the UV protection property and photostability were investigated and compared with BMBM/OMC-conventional emulsions. The particle size and ZP of BMBM/OMC-loaded NLC were 310.24 nm and -33.6 mV, EE of BMBM and OMC were 85.46% and 99.32%. SEM, FTIR and DSC analysis confirmed BMBM and OMC entrapped in the lipid matrix core and the structure was stable during storage. Compared with conventional emulsion, BMBM/OMC-loaded NLC displayed perfect photo protection property in whole UV range. The photostability studies showed that the NLC can improve the photostability of sunscreens.
A new photoprotective system based on encapsulating UVA(butyl methoxydibenzoylmethane,BMBM)and UVB(octyl methoxycinnamate,OMC) filters into nanostructured lipid carriers(NLC) has been prepared to develop cosmetic formulations with effective UV protection.BMBM/OMC-loaded NLC was prepared by ultrasonication-homogenisation,and analysed by particle size,zeta potential(ZP),encapsulation efficiency(EE),scanning electron microscopy(SEM),fourier transform infrared spectroscopy(FTIR) and differential scanning calorimetry(DSC).Moreover,the UV protection property and photostability were investigated and compared with BMBM/OMC-conventional emulsions.The particle size and ZP of BMBM/OMC-loaded NLC were 310.24 nm and-33.6 mV,EE of BMBM and OMC were 85.46% and 99.32%.SEM,FTIR and DSC analysis confirmed BMBM and OMC entrapped in the lipid matrix core and the structure was stable during storage.Compared with conventional emulsion,BMBM/OMC-loaded NLC displayed perfect photo protection property in whole UV range.The photostability studies showed that the NLC can improve the photostability of sunscreens.
基金
supported by Base Construction Program of Shanghai Institute of Technology:Breeding of new variety and Highyield Cultivation Technique of Fragrant Plants (3921NH166035)
