托拉塞米联合多巴胺对顽固性心力衰竭患者心脏结构及功能的影响

Effect of torasemide combined with dopamine on cardiac structure and function in patients with refractory heart failure

目的观察托拉塞米联合多巴胺治疗顽固性心力衰竭的临床疗效。方法选取我院86例顽固性心力衰竭患者为研究对象,将其随机分为对照组和观察组,各43例。对照组给予托拉塞米,观察组在对照组基础上联合多巴胺进行治疗。比较两组患者的临床疗效和治疗前、后心功能指标变化。结果观察组患者的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组患者的LVEF均升高,LVESD及LVEDD均降低,且观察组优于对照组(P<0.05)。治疗后,两组患者的BNP、PRA和AngⅡ水平均显著降低,且观察组显著低于对照组(P<0.05)。结论托拉塞米联合多巴胺治疗顽固性心力衰竭能够有效改善患者临床症状,不同程度改善患者心功能,值得临床推广应用。

Objective To observe the clinical efficacy of torasemide combined with dopamine in the treatment of refractory heart failure.Methods Eighty-six patients with refractory heart failure were randomly divided into control group and observation group, with 43 cases in each group.The control group was given torasemide, and the observation group was combined with dopamine treatment on the basis of control group.The clinical efficacy and changes of cardiac function indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment, LVEF increased, LVESD and LVEDD decreased in both groups, and those of the observation group were better than the control group(P<0.05).After treatment, the levels of BNP, PRA and Ang II in both groups significantly decreased, and those of the observation group were significantly lower than the control group(P<0.05).Conclusion Torasemide combined with dopamine in the treatment of patients with refractory heart failure can effectively improve the clinical symptoms and cardiac function, which is worthy of clinical application.