噻托溴铵联合舒利迭对COPD急性期并发呼吸衰竭患者肺功能的改善作用

Improvement effect of tiotropium bromide combined with seretide on lung function in patients with acute exacerbation of COPD and respiratory failure

目的分析噻托溴铵联合舒利迭对慢性阻塞性肺疾病(COPD)急性期并发呼吸衰竭患者肺功能的改善作用。方法将我院收治的96例COPD急性期并发呼吸衰竭患者随机分为对照组与研究组,各48例。对照组采用舒利迭治疗,研究组采用噻托溴铵联合舒利迭治疗。对比两组治疗前、后的炎症因子水平和肺功能指标,并比较两组的临床疗效。结果治疗后,两组的血清IL-6及CRP水平均降低,FVC、FEV_1和PEFR水平均升高,且研究组均优于对照组(P<0.05)。研究组的治疗总有效率高于对照组(P<0.05)。结论噻托溴铵联合舒利迭治疗COPD急性发作期并发呼吸衰竭的效果显著,可降低患者的炎症因子水平,改善肺功能。

Objective To analyze the improvement effect of tiotropium bromide combined with seretide on lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and respiratory failure.Methods Ninety-six patients with acute exacerbation of COPD and respiratory failure admitted in our hospital were randomly divided into control group and study group, with 48 cases in each group.The control group was treated with seretide, while the study group was treated with tiotropium bromide and seretide.The levels of inflammatory factors and pulmonary function indexes before and after treatment were compared between the two groups, and the clinical efficacy of the two groups were compared.Results After treatment, the levels of serum IL-6 and CRP in both groups decreased, the levels of FVC, FEV1 and PEFR increased in both groups, and those in the study group were better than the control group(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion Tiotropium bromide combined with seretide in the treatment of acute exacerbation of COPD and respiratory failure has a significant effect, which can decrease the levels of inflammatory factors of patients and improve lung function.