补血荣筋汤加减联合阿伦磷酸钠对骨质疏松症伴胸腰椎骨折患者术后骨代谢指标的影响

Effect of modified Buxue Rongjin decoction combined with alendronate on bone metabolism indexes in patients with osteoporosis and thoracolumbar fractures

目的探讨骨质疏松症伴胸腰椎骨折患者术后给予补血荣筋汤加减联合阿伦磷酸钠治疗对骨代谢指标的影响。方法将93例骨质疏松症伴胸腰椎骨折患者根据随机数字表法分为对照组(n=46,阿伦磷酸钠)与研究组(n=47,补血荣筋汤加减联合阿伦磷酸钠)。比较两组患者的治疗效果。结果治疗后,两组骨特异性碱性磷酸酶(BAP)和骨钙素(BGP)水平均高于治疗前,且研究组高于对照组(P<0.05);治疗后,两组Ⅰ型胶原C端肽(CTX-Ⅰ)水平均低于治疗前,且研究组低于对照组(P<0.05)。研究组下床活动时间、骨折愈合时间和完全负重行走时间短于对照组(P<0.05)。研究组骨折再发率低于对照组(P<0.05)。结论对骨质疏松症伴胸腰椎骨折患者术后给予补血荣筋汤加减联合阿伦磷酸钠治疗能够显著改善骨代谢指标,加快恢复,减少骨折再发。

Objective To explore the effect of modified of Buxue Rongjin decoction combined with alendronate on bone metabolism indexes in patients with osteoporosis and thoracolumbar fractures.Methods A total of 93 cases of osteoporosis with thoracolumbar fractures were divided into control group (n=46, alendronate) and study group (n=47, modified Buxue Rongjin decoction combined with alendronate ) according to the random number table method.The treatment effects of the two groups were compared.Results After treatment, the levels of bone specific alkaline phosphatase (BAP) and bone gla protein (BGP) in the two groups were higher than those before treatment, and those in the study group were higher than the control group (P<0.05).After treatment, the level of C-terminal peptide of type Ⅰcollagen (CTX-Ⅰ) in both groups was lower than that before treatment, and that in the study group was lower than the control group (P<0.05).The time of getting out of bed, fracture healing and walking with full load in the study group were shorter than those in the control group (P<0.05).The fracture recurrence rate in study group was lower than that in control group (P<0.05).Conclusion Modified Buxue Rongjin decoction combined with alendronate can significantly improve the bone metabolism indexes in patients with osteoporosis and thoracolumbar fractures, accelerate the recovery and reduce the recurrence of fractures.