探讨COX-2在卵巢上皮性癌中的表达及临床意义

Investigation of the Expression and Clinical Significance of COX-2 in Epithelial Ovarian Cancer

目的探讨COX-2在卵巢上皮性癌中的表达及临床意义,为临床上卵巢疾病的确诊提供科学理论依据。方法方便选择2016年8月—2018年4月在该院治疗的59例卵巢上皮性癌、22例卵巢良性上皮性肿瘤及9例正常卵巢组织的患者为研究对象,采用免疫组化法检测其COX-2的表达。结果正常组织中未见COX-2蛋白的表达。COX-2蛋白在卵巢癌及良性上皮性肿瘤中的阳性表达率分别为61.01%和27.27%,卵巢上皮癌中阳性率明显高于良性上皮性肿瘤及正常组织,差异有统计学意义(P<0.05)。结论 COX-2的表达和卵巢上皮性癌的发生有密切的关系,根据COX-2的阳性表达情况可以初步诊断患者的卵巢疾病情况,值得在临床上诊断卵巢疾病的应用推广。

Objective To investigate the expression and clinical significance of COX-2 in epithelial ovarian cancer,and to provide scientific theoretical basis for the diagnosis of clinical ovarian disease.Methods A total of 59 patients with ovarian epithelial cancer,22 case ovarian benign epithelial tumors and 9 case normal ovarian tissues treated in the hospital from August 2016 to April 2018 were enrolled in this study.The COX-2 expression was detected by immunohistochemistry.Results No expression of COX-2 protein was observed in normal tissues.The positive expression rates of COX-2 protein in ovarian cancer and benign epithelial tumors were 61.01% and 27.27%.The positive rate of ovarian epithelial cancer was significantly higher than that of benign epithelial.Tumor and normal tissues,were statistically significant(P<0.05).Conclusion The expression of COX-2 is closely related to the occurrence of epithelial ovarian cancer.According to the positive expression of COX-2,the ovarian disease can be diagnosed initially.It is worthy of clinical application in the diagnosis of ovarian disease.