妇科门诊治疗细菌性阴道病的效果研究

Effect Effect of Gynecological Clinic on Bacterial Vaginosis

目的研究妇科门诊治疗细菌性阴道病的临床效果。方法方便选取100例该院门诊2015年6月—2017年9月期间收治的细菌性阴道病患者,随机纳入对照组和试验组,各50例。对照组以甲硝唑口服完成治疗,试验组以甲硝唑口服及克林霉素阴道用药完成治疗。比较两组治疗总有效率,比较两组治疗前后乳杆菌属和致病菌检出率,比较两组不良反应发生率,并比较两组复发率。结果试验组治疗总有效率为92.00%,高于对照组74.00%的治疗总有效率,数据差异有统计学意义(χ~2=5.740 6,P=0.016 5)。试验组治疗前乳杆菌属和致病菌检出率分别为8.00%和96.00%,对照组分别为8.00%和94.00%,治疗后试验组乳杆菌属和致病菌检出率分别为28.00%和2.00%,对照组分别为12.00%和14.00%,两组治疗前乳杆菌属和致病菌检出率差异无统计学意义(P>0.05),治疗后两组均得到明显改善,但试验组治疗后检出率均优于对照组,数据差异有统计学意义(P<0.05)。试验组不良反应发生率为10.00%,高于对照组8.00%的发生率,但数据差异无统计学意义(χ~2=0.122 1,P=0.726 7)。试验组复发率为4.00%,低于对照组22.00%的复发率,数据差异有统计学意义(χ~2=7.161 8,P=0.007 4)。结论妇科门诊采用甲硝唑与克林霉素联合治疗细菌性阴道病效果较好,能有效改善患者阴道菌群失衡,降低治疗后复发率,具有较高临床价值。

Objective To study the clinical effect of gynecological outpatients in the treatment of bacterial vaginosis.Methods 100 patients with bacterial vaginosis admitted to the hospital from June 2015 to September 2017 were conveniently selected and randomly included in the control group and the experimental group.The control group was treated with metronidazole orally.The experimental group was treated with metronidazole orally and clindamycin.The total effective rate of the two groups was compared.The detection rates of Lactobacillus and pathogenic bacteria before and after treatment were compared.The incidence of adverse reactions was compared between the two groups,and the recurrence rates of the two groups were compared.Results The total effective rate of the treatment group was 92.00%,which was higher than the total effective rate of 74.00% of the control group.The data were significantly different (χ^2=5.740 6,P=0.016 5).The detection rates of Lactobacillus and pathogenic bacteria in the experimental group were 8.00% and 96.00%,respectively,and the control group was 8.00% and 94.00%,respectively.After treatment,the detection rate of Lactobacillus and pathogenic bacteria in the experimental group was 28.00%.And 2.00%,the control group was 12.00% and 14.00% respectively.There was no significant difference in the detection rate of Lactobacillus and pathogenic bacteria between the two groups (P>0.05).After treatment,the two groups were significantly improved,but the experimental group was treated.The post-detection rate was superior to the control group,and the data were significantly different (P<0.05).The incidence of adverse reactions in the experimental group was 10.00%,which was higher than the incidence of 8.00% in the control group,but the difference was not significant (χ^2=0.122 1,P=0.726 7).The recurrence rate of the test group was 4.00%,which was lower than the recurrence rate of 22.00% in the control group.The data were significantly different (χ^2=7.161 8,P=0.007 4).Conclusion The combination of metronidazole and clindamycin in the treatment of bacterial vaginosis is better in gynecological clinics.It can effectively improve the vaginal flora imbalance and reduce the recurrence rate after treatment.It has high clinical value.