研究阿瑞匹坦用于含顺铂方案肺癌患者的止吐效果

Study on the Antiemetic Effect of Aprepitant in Patients with Lung Cancer Containing Cisplatin Regimen

目的探讨含顺铂化疗方案肺癌患者应用阿瑞匹坦的止吐效果。方法方便选取该院于2016年8月—2017年8月间收治的肺癌患者94例,对其资料进行回顾性分析,对照组有40例,采取含顺铂方案(托烷司琼联合地塞米松)治疗,研究组有54例,在与对照组相同含顺铂方案基础上,给予阿瑞匹坦治疗,比较两组患者化疗周期内的呕吐情况。结果在急性呕吐治疗有效率上,研究组为83.3%,对照组为77.5%,研究组数值高于对照组,差异无统计学意义(P>0.05);在延迟性呕吐治疗有效率上,研究组为92.6%,显著高于对照组75.0%,差异有统计学意义(χ~2=5.837,P<0.05)。研究组患者治疗总不良反应47.5%低于对照组患者治疗总不良反应18.5%,差异有统计学意义(χ~2=9.047,P<0.05)。研究组患者生活质量评分均高于对照组患者,差异有统计学意义(P<0.05)。结论对于采取含顺铂方案治疗的肺癌患者,服用阿瑞匹坦可以改善患者的呕吐症状,特别是延迟性呕吐,效果显著,能够提高患者生活质量,值得临床推广应用。

Objective To investigate the antiemetic effect of aprepitant in lung cancer patients with cisplatin chemotherapy.Methods A total of 94 patients with lung cancer admitted to the hospital from August 2016 to August 2017 were convenient selected.The data were retrospectively analyzed.40 patients in the control group were treated with cisplatin.There were 54 patients in the study group.On the basis of the same cisplatin regimen as the control group,aprepitant was given to compare the vomiting in the chemotherapy period between the two groups.Results 1.In the effective treatment of acute vomiting,the study group was 83.3%,and the control group was 77.5%.The study group was higher than the control group,but the difference was not significant (P>0.05).In the treatment of delayed vomiting,The study group was 92.6%,which was significantly higher than the control group (75.0%),and the difference was statistically significant (χ^2=5.837,P<0.05).2.The total adverse reactions in the study group were 47.5% lower than those in the control group (18.5%),and the difference was statistically significant (χ^2=9.047,P<0.05).3.The quality of life scores of the study group were higher than those of the control group,and the difference was statistically significant (P<0.05).Conclusion For patients with lung cancer treated with cisplatin,taking aprepitant can improve the patient's vomiting symptoms,especially delayed vomiting,and the effect is significant,which can improve the quality of life of patients,which is worthy of clinical application.