臭氧化合成聚乙二醇醛基衍生物

Synthesis of Polyethylene Glycol Aldehyde Derivatives by Ozonation

以甲氧基聚乙二醇为原料,通过烯烃化得到甲氧基聚乙二醇烯烃,最后经臭氧化反应得到甲氧基聚乙二醇醛基衍生物。通过核磁共振波谱仪(NMR)和基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)对产物的结构和性能进行了表征。结果表明,该方法合成的产物纯度高,无副产物,甲氧基聚乙二醇乙醛和聚乙二醇丙醛的产率分别高达98%和99%,取代度分别为90. 87%～99. 91%和98%～100%。

Methoxypolyethylene glycol olefin was obtained by olefination of methoxypolyethylene glycol,and followed by ozonation to give methoxypolyethylene glycol aldehyde derivative.The properties of products were characterized by nuclear magnetic resonance spectroscopy(NMR)and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS).The results show that the product has high purity and no by-products.The yields of methoxy polyethylene glycol acetaldehyde and polyethylene glycol propionaldehyde are as high as 98% and 99%,respectively,and the degrees of substitution are 90.87%~99.91% and 98%~100%,respectively.