MAIT在自身免疫性疾病中的研究进展

Advances in research of MAIT in autoimmune diseases

自身免疫性疾病(AID)的发病机制复杂,目前仍不十分清楚。黏膜相关恒定T细胞(MAIT cells)是一群进化保守的固有样T淋巴细胞,被发现参与到1型糖尿病、自身免疫性肝病、强直性脊柱炎、多发性硬化症、系统性红斑狼疮、类风湿性关节炎等AID的病理机制和疾病进程。

The pathogenesis of autoimmune diseases(AID)is complex and remains unclear.Mucosal-associated invariant T cells(MAIT cells)are a group of evolutionarily conserved intrinsic T lymphocytes those were found to be involved in the pathological mechanism and disease progression of AID,including type 1 diabetes,autoimmune liver disease,ankylosing spondylitis,multiple sclerosis,systemic lupus erythematosus,rheumatoid arthritis and so on.