多种血清肿瘤标志物联合检测在肺癌诊断中的应用研究

Application of combined detection of multiple serum tumor markers in the diagnosis of lung cancer

目的探讨多种血清肿瘤标志物——癌胚抗原(CEA)、细胞角蛋白-19片断抗原(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC-Ag)、胃泌素释放肽前体(Pro-GRP)和神经元特异性烯醇化酶(NSE)联合检测在肺癌诊断中的临床应用价值。方法选择该院2015年12月至2017年10月收治的肺癌患者120例(肺癌组)、肺部良性病变患者40例(良性肺疾病组)和来院体检的健康者40例(健康对照组)作为研究对象,采用电化学发光法分别检测3组患者血清CEA、CYFRA21-1、SCC-Ag、Pro-GRP和NSE水平,并进行比较。结果肺癌组患者血清CEA、CYFRA21-1、SCC-Ag、Pro-GRP和NSE水平均显著高于良性肺疾病组和健康对照组,差异均有统计学意义(P<0.05)。CEA、CYFRA21-1、SCC-Ag、Pro-GRP和NSE单独检测的灵敏度分别为49.2%、74.2%、42.5%、55.0%和20.8%,而5种指标联合检测的灵敏度为97.5%。结论 CEA、CYFRA21-1、SCCAg、Pro-GRP和NSE的联合检测灵敏度高,临床应用价值较高,能有效提高肺癌的临床检出率,对早期肺癌的诊断具有重要意义。

Objective To investigate the clinical value of combined detection of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE in the diagnosis and treatment of lung cancer.Methods 120 patients with lung cancer and 40 patients with benignant lung diseases,which are received and cured in a hospital from December,2015 to October,2017.At the same time,40 healthy people were recruited when they were undergoing healthy examination as the control group.Then we detected and compared the levels of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE in the blood with electrochemiluminescence immunoassay respectively.Results The levels of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE in the lung cancer group were higher than that in the benignant lung disease group and control group,and the difference reached statistical significance(P<0.05).The sensitivity values of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE were 9.2%,74.2%,42.5%,55.0%,20.8%,and the sensitivity of combined determination containing CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE was 97.5%.Conclusion The joint detection of CEA,CYFRA21-1,SCC-Ag,Pro-GRP and NSE can improve the relevance ratio of lung cancer and it has important value in the diagnosis of lung cancer.