氧化应激对动物有腔卵泡闭锁的影响及机制

Effect of oxidative stress on antral follicular atresia in animals and its mechanism

氧化应激被认为是影响动物繁殖性能和造成人类不孕不育的重要因素,氧化应激诱导卵泡颗粒细胞凋亡,进而诱发卵泡闭锁是其影响动物繁殖性能的重要途径。近年来,针对氧化应激对有腔卵泡闭锁的影响研究取得了系列进展,主要包括:氧化应激对卵泡闭锁具有重要调控作用;叉头盒转录因子O1(FoxO1)是氧化应激诱发卵泡闭锁的关键性调控因子;卵泡液因子能够调控卵泡颗粒细胞氧化损伤的发生与程度。

Oxidative stress is considered to be an important factor affecting animal reproductive performance and causing infertility in humans. Oxidative stress induces apoptosis of follicular granulosa cells,which in turn induces follicular atresia as an important way to influence animal reproductive performance. In recent years,a series of research progress has been made on the effects of oxidative stress on antral follicular atresia,including:oxidative stress plays an important role in regulating follicular atresia;transcription factor forkhead box O1(FoxO1)is a key regulator of oxidative stress-induced follicular atresia;follicular fluid factors can regulate the occurrence and degree of oxidative damage of follicular granule cells.