腹腔镜手术联合GnRH-a治疗子宫内膜异位症的临床研究

Clinical study of laparoscopic surgery combined with GnRH-a in the treatment of endometriosis

目的探讨腹腔镜手术联合GnRH-a治疗子宫内膜异位症的临床效果。方法选取50例拟行腹腔镜手术治疗的EMT的患者随机等分为观察组与对照组,对照组仅予以腹腔镜术治疗,观察组在腹腔镜术后予以GnRHa治疗,对比两组治疗效果。结果观察组妊娠率76.0%、自然分娩率36%多于对照组,流产率4.0%、宫外孕率4.0%、早产率4.0%、剖宫产率8.0%少于对照组,两组比较差异具有统计学意义(P <0.05)。观察组、对照组在治疗前的卵巢功能相关指标比较中,均无明显差异(P> 0.05),在治疗后比较中,雌二醇差异明显(P <0.05),黄体生成素、卵泡刺激素差异无统计学意义(P> 0.05)。观察组治疗后的婚姻质量评分高于对照组,两组比较差异具有统计学意义(P <0.05)。结论腹腔镜术后GnRH-a治疗能够改善EMT合并不孕患者的妊娠结局,提高其婚姻质量,值得推广。

Objective: To investigate the clinical effect of laparoscopic surgery combined with GnRH-a in the treatment of endometriosis. Methods: 50 patients scheduled for laparoscopic surgery for patients with EMT were randomly divided into observation group and control group,the control group only received laparoscopic treatment,in the observation group after laparoscopic surgery received GnRH-a treatment,compared two groups of treatment effect. Results: The observation group the pregnancy rate was 76%,the rate of natural childbirth 36% more than the control group,the abortion rate,ectopic pregnancy rate of 4%,4%,4% preterm delivery rate and cesarean section rate was 8% less than that of the control group,with significant differences between the two groups( P < 0. 05). The observation group and control group in the treatment of ovarian function before the related index comparison,showed no significant difference( P > 0. 05),after treatment in comparison,estradiol significantly( P < 0. 05),no statistical significance of luteinizing hormone and follicle stimulating hormone difference( P > 0. 05). The marital quality score of the observation group after treatment was higher than that of the control group,and the difference between the two groups was statistically significant( P < 0. 05). Conclusion: GnRH-a treatment after laparoscopic surgery can improve the pregnancy outcome of EMT patients with infertility and improve their marital quality,which is worthy of promotion.