术后吉兰-巴雷综合征的临床及电生理特征分析

Clinical and electrophysiological characteristics of postoperative Guillain-Barre syndrome

目的分析术后吉兰-巴雷综合征(GBS)的临床特征以期指导临床诊疗。方法回顾性分析2013-11—2016-11郑州大学第一附属医院的10例手术后GBS病例,总结其临床表现、神经电生理结果、血清学指标、腰穿实验室检查结果及预后特点。结果所有患者都有不同程度的运动功能受累,其中6例呼吸肌受累,6例同时损伤脑神经,6例血清抗神经节苷脂抗体阳性,7例出现并发症,电生理异常以轴索损伤为主。部分患者预后不良。结论由非感染因素如手术引起的GBS在临床中易被忽视,部分预后差。准确把握术后GBS的临床及神经电生理特征对于诊断及治疗十分重要。

Objective To analyze the clinical features of postoperative Guillain Barrésyndrome(GBS)in order to guide clinical diagnosis and treatment.Methods A retrospective analysis of 10 cases of postoperative GBS cases from the First Affiliated Hospital of Zhengzhou University from November 2013 to November 2016 was conducted.The clinical manifestations,neurophysiological results,serological indexes,lumbar puncture laboratory results and prognosis were summarized.Results All patients had different degrees of motor function involvement,including 6 cases of respiratory muscle involvement,6 cases of cranial nerve injury at the same time,6 cases of serum anti ganglioside antibody positive,7 cases of complications,electrophysiological abnormalities with mainly axonal injury.Some patients have a poor prognosis.Conclusion GBS caused by non infective factors,such as surgery,is easily overlooked in the clinic,and some prognosis is poor.Accurate understanding of the clinical and neurophysiological characteristics of postoperative GBS is important for diagnosis and treatment.