Swiprosin-1的研究进展及其生物学作用

Research progress and biological functions of Swiprosin-1

Swiprosin-1/EFhd2是一种Ca2+结合蛋白,参与多种细胞功能。在许多炎症疾病、神经退行性疾病和癌症中,Swiprosin-1的表达显著上调。本综述概述了Swiprosin-1/EFhd2在各种病理生理条件下的表达及功能以及Swiprosin-1在免疫细胞活化、细胞迁移、凋亡、肿瘤侵袭和细胞转移、神经元传输等方面的作用。

Swiprosin-1/EFhd2 is a Ca^2+binding adapter protein involved in the various cellular functions.Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation,neurodegeneration,and cancer.This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions.We also discussed the key role of swiprosin-1 in immune cell activation,cell migration,apoptosis,cancer invasion and metastasis and neuronal transport.