肝脏缺血再灌注损伤分子机制的研究进展

Advances in molecular mechanisms of liver ischemia reperfusion injury

缺血再灌注损伤(IRI)是肝移植术中不可避免的病理生理变化,是引起肝损伤的一个重要原因,可能导致肝功能衰竭,影响肝移植受者术后的近、远期疗效。参与肝脏缺血再灌注的分子进程复杂多样,所涉及的机制在很大程度上尚未阐明,并不断有新的复杂机制更新。本综述旨在总结一些重要的分子机制在肝脏IRI中的研究进展,同时概述减轻IRI的新兴策略,为临床提高肝移植疗效及移植肝生存率,提供理论和科学依据。

Ischemia reperfusion injury( IRI) represents the main cause of liver damage during surgical procedures such as hepatic resection and liver transplantation,it is an inevitable process of liver transplantation,which may lead to liver function failure and affect the postoperative short-term and long-term efficacy of liver transplant recipients. The molecular mechanisms occurring during hepatic ischemia reperfusion are largely unknown and keeping update. This review aims to summarize some significant molecular mechanisms in research progress of liver IRI. In addition,some new strategies for alleviating IRI are outlined to provide theoretical and scientific basis for clinical improvement of postoperative graft survival rate and liver transplantation curative effect.