Hepcidin蛋白与乳腺癌骨转移的关系

Role of Hepcidin in bone metastasis of breast cancer

目的分析乳腺癌及乳腺癌骨转移患者的Hepcidin蛋白及相关指标,探讨Hepcidin在乳腺癌发生、发展中的作用。方法回顾性分析江苏省常州市第一人民医院乳腺癌骨转移患者25例、乳腺癌无骨转移患者30例及乳腺增生患者30例。比较3组患者Hb、Hepcidin、BMP-6、IL-6、s Tf R的差异。用ROC曲线分析评价Hepcidin、BMP-6、IL-6对乳腺癌骨转移的诊断价值。多因素Logistic回归分析比较各指标在乳腺癌骨转移的作用。结果 3组患者Hb、Hepcidin、BMP-6、IL-6、s Tf R差异有统计学意义(P <0.05)。对Hepcidin及BMP-6,乳腺癌骨转移组>乳腺癌无骨转移组>乳腺增生组;对IL-6,乳腺癌骨转移组>乳腺癌无骨转移组及乳腺增生组,但后两组比较差异无统计学意义(P>0.05);对Hb,乳腺癌骨转移组<乳腺癌无骨转移组<乳腺增生组;对于s Tf R,乳腺癌骨转移组<乳腺癌无骨转移组<乳腺增生组。ROC曲线分析发现Hepcidin对于乳腺癌骨转移均有较高诊断价值,且优于BMP-6、IL-6。多因素分析发现Hepcidin是乳腺癌骨转移的独立危险因素。结论Hepcidin与乳腺癌骨转移有较好的相关性,其诊断价值有待进一步研究。

Objective To investigate role of Hepcidin in bone metastases of breast cancer and its clinical significance.Methods A retrospective analysis of 25 breast cancer patients with bone metastases,30 breast cancer patients without bone metastases,and 30 patients with breast hyperplasia was conducted.Levels of Hb,Hepcidin,BMP-6,IL-6,and sTfR were measured.Statistical analysis was performed to evaluate the diagnostic value of Hepcidin,BMP-6 and IL-6 in bone metastasis in breast cancer.Results Patients with bone metastasis experienced highest levels of Hepcidin,BMP-6 and IL-6,followed by patients without bone metastasis and patients with breast hyperplasia (P<0.05).Patients with breast hyperplasia experienced highest levels of Hb and sTfR,followed by patients without bone metastasis and patients with breast hyperplasia (P<0.05).ROC analysis showed that Hepcidin was superior to BMP-6 and IL-6 as a diagnostic marker for breast cancer with bone metastasis.Multivariate analysis showed that Hepcidin was an independent risk factor for breast cancer with bone metastasis.Conclusion Hepcidin may be a promising diagnostic biomarker for bone metastasis of breast cancer.