儿童难治性肺炎支原体肺炎混合感染的临床特点分析

The clinical characteristics and risk factors of mixed infection of refractory Mycoplasma pneumonia in children

目的:探讨儿童难治性肺炎支原体肺炎混合感染的临床特点及危险因素。方法:以202例难治性肺炎支原体肺炎患儿为研究对象,通过回顾性分析患儿的临床资料,对比观察混合感染组(46例)与非混合感染组(156例)发热时间、炎性反应指标以及并发症发生率的差异。全部患儿均行纤维支气管镜检查联合肺泡灌洗术。结果:混合感染组住院时间(24. 3±5. 7) d、GRN%(0. 8±0. 3)%、CRP(54. 7±51. 8) mg/L、肺不张23. 9%、胸腔积液37. 0%、肝功能损害10. 9%,各项指标均高于非混合感染组的住院时间(17. 6±5. 2) d、CRN%(0. 4±0. 2)%、CRP(23. 4±22. 6) mg/L、肺不张9. 61%、胸腔积液14. 1%、肝功能损害3. 2%,差异有统计学意义(P <0. 05)。结论:混合感染会使难治性肺炎支原体肺炎的发热时间延长,全身炎性反应加重,肺内外并发症发生率增加,使住院时间延长。

Objective To investigate the clinical characteristics and risk factors of mixed infection of refractory Mycoplasma pneumonia in children.Method A total of 202 children with refractory Mycoplasma pneumonia were selected as subjects of study.The clinical data were analyzed retrospectively.Fever duration,inflammation index and complication rate of the children with mixed infection and non-mixed infection were analyzed.All patients underwent bronchoscopy and alveolar lavage.Results Patients in mixed infection group had a longer duration of hospitalization time(24.3±5.7)d,higher percentage of GRN(0.8±0.3)%,CRP(54.7±51.8)mg/L,atelectasis(23.9%),pleural effusion(37.0%)and liver function impairment(10.9%)compared with hospitalzation time(17.6±5.2)d,GRN(0.4±0.2)%,CRP(23.4±22.6)mg/L,atelectasis(9.61%),plaural effusion(14.1%)and liver function impairment(3.2%)of the non-mixed infection group(P<0.05).Conclusion In patients with refractory Mycoplasma pneumonia,mixed infection can prolong the fever time,increase the inflammation and the incidence of complications and prolong the hospitalization time.