慈菇消脂胶囊对NAFLD大鼠肝组织病理变化及肝功能、血脂、FFA的影响

Effects of Cigu Xiaozhi Capsule(慈菇消脂胶囊) on Liver Tissue Pathological Changes,Hepatic Function,Blood Lipid and FFA of NAFLD Rats

目的:通过观察慈菇消脂胶囊对非酒精性脂肪性肝病(NAFLD)模型大鼠肝组织病理变化、肝功能及血脂、FFA(游离脂肪酸)的影响,探讨慈菇消脂胶囊防治该病的作用机理。方法:喂饲高脂饲料复制非酒精性脂肪肝模型,70只大鼠随机分为正常组,模型组,慈菇消脂胶囊高剂量组、中剂量组、低剂量组和吡格列酮阳性药物对照组,各组大鼠连续给药6周,观察各组大鼠肝组织病理形态学变化;检测肝功能、血脂水平和肝组织FFA含量。结果:与正常组比较,模型组肝脏病理学变化、血脂代谢、肝功能指标和肝组织FFA变化均具有统计学意义(P <0. 05);慈菇消脂胶囊各剂量组肝脏脂肪变性和炎症均有不同程度的减轻,TC、TG、LDL水平及FFA含量较模型组降低(P <0. 05),差异具有统计学意义(P <0. 05)。结论:慈菇消脂胶囊能够改善肝功能,减轻肝细胞脂肪变性,对非酒精性脂肪性肝病的治疗作用确切。

Objective: To explore the mechanism of Cigu Xiaozhi Capsule on nonalcoholic fatty liver disease( NAFLD) by observing the effects of the Capsule on pathological changes of liver tissue,hepatic function,blood lipid and FFA expression in NAFLD rats. Methods: NAFLD models were copied by giving high-fat diet,70 rats were divided into normal,model,Cigu Xiaozhi Capsule low,middle and high dose groups,each group was given the corresponding medicine for 6 weeks,the pathological changes of liver tissue were observed by optical microscope,serum ALT,AST and Blood lipid( TC,TG,HDL,LDL) levels were determined,FFA expression was determined. Results: To compare with normal group,the liver tissue pathological changes,blood lipid,ALT,AST and liver tissue FFA expression in model group were significantly changed( P < 0. 05),the hepatic steatosis and inflammation of the three dose Cigu Xiaozhi Capsule groups were alleviated at different degree,TG,TC,LDL and FFA were decreased( P < 0. 05). Conclusion: Cigu Xiaozhi Capsule can prevent NAFLD by improving hepatic function and alleviating hepatic steatosis.