基于中医传承辅助平台分析含黄连-干姜药对方剂的组方规律

Prescription Rules for the Prescriptions Containing Coptis chinensis-Zingber ojjicinale Couplet Medicine Based on TCM Inheritance Support Platform

目的:为含黄连-干姜药对(简称"黄连-干姜")方剂的后续产品开发提供理论依据。方法:收集整理《中医方剂大辞典》中包含黄连-干姜的方剂,录入中医传承辅助平台软件(V2.5)建立数据库,统计主治疾病频次、配伍药材频次;采用关联规则Apriori算法对含黄连-干姜方剂药材核心组合进行统计分析(设置支持度分别为15%、20%、25%,置信度为0.90);选择频次排前2位的主治疾病和配伍药材频次最高的温里药和清热药进行组方规律分析。结果:共筛选出492首含黄连-干姜方剂,涉及主治疾病9种(频次≥15),包括痢疾、泄泻、积聚、痞满等;常用配伍药材21味(频次≥55),包括当归、厚朴、附子、黄芩等;常用药材组合有19个,其中核心药材组合包括黄连-干姜-人参、黄连-干姜-厚朴、黄连-干姜-当归;常与黄连-干姜配伍治疗痢疾的核心药材有5种,治疗泄泻的核心药材有9种;在黄连-干姜配伍温里药附子的方剂中核心药材有8种,在配伍清热药黄芩的方剂中核心药材有7种。结论:含黄连-干姜药对方剂主治疾病以消化道疾病为主;该药对可配伍不同药材用于不同疾病的治疗;本研究可为其后续产品的开发提供理论依据。

OBJECTIVE:To provide a theoretical basis for the development of the following products of Coptis chinensis-Zingiber ojjicinale couplet medicine(“Coptis chinensis-Zingiber ojjicinale”for short)prescription.METHODS:The prescriptions containing Coptis chinensis-Zingiber ojjicinale were collected from the Dictionary of TCM Prescription and input into TCM inheritance support platform software(V2.5)to establish the database.The frequency of major diseases and compatibility medicinal materials were analyzed statistically.The core combination of medicinal materials in the prescriptions containing Coptis chinensis-Zingiber ojjicinale were analyzed statistically with association rule Apriori algorithm(support degrees were 15%,20%,25%,confidence was 0.90).Top 2 main diseases in the list of frequency,compatibility medicinal materials for dispelling internal cold and medicine for clearing heat with highest compatibility frequency were selected and analyzed in respect of prescription rules.RESULTS:A total of 492 prescriptions containing Coptis chinensis-Zingiber ojjicinale were screened,9 kinds of major diseases(frequency≥15),such as dysentery,diarrhea,accumulation,fullness.There were 21 commonly used compatibility medicinal materials(frequency≥55),including Angelica sinensis-Panax ginseng,Magnolia officinalis,Aconitum carmichaelii,Scutellaria baicalensis,etc.There were 19 commonly used medicinal materials combinations,including Coptis chinensis-Zingiber ojjicinale-Panax ginseng,Coptis chinensis-Zingiber ojjicinale-Magnolia officinalis,Coptis chinensis-Zingiber ojjicinale-Angelica sinensis.There are 5 kinds of core medicinal materials commonly used in treating dysentery with Coptis chinensis-Zingiber ojjicinale,and 9 kinds of core medicinal materials for treating dysentery.There are 8 kinds of core medicinal materials in Coptis chinensis-Zingiber ojjicinale compatible with medicine for dispelling internal cold Aconitum carmichaelii prescription.and 7 core medicinal materials in compatible with medicine for clearing heat Scutellaria baicalensis prescription.CONCLUSIONS:The major diseases treated with prescriptions containing Coptis chinensis-Zingiber ojjicinale are mainly digestive tract diseases.It can treat different diseases being compatible with different medicinal materials,this study aslo can provide theoretical basis for the development of subsequent products.