氮杂环卡宾催化的不对称安息香缩合反应

N-Heterocyclic Carbene Catalyzed Asymmetric Benzoin Reaction

氮杂环卡宾在催化反应中扮演着重要角色,是有机反应的高效催化剂。本文主要介绍氮杂环卡宾的类型、手性三氮唑卡宾的合成及其催化的不对称安息香缩合反应。目的在于通过延伸本科教学内容,开拓大学生的知识视野,充分感受有机化学的魅力;通过对已有知识的整理、归纳、思考,提高发现问题、分析问题和解决问题的能力。

N-Heterocyclic carbene(NHC) plays an important role in catalytic processes, as the catalyst it has shown high activities in organic reactions. Synthesis of chiral triazole carbene, the structure and the application of NHCs in asymmetric catalytic benzoin reactions are described. The aims are to broad students’ vision and make students feel the charm of organic chemistry through extension of undergraduate curriculum content. Meanwhile, their ability of finding, analyzing and solving problems on the basis of generalizing and thinking about the knowledge will be improved.