早期肠内营养对脑出血患者免疫功能的影响

Influence of early enteral nutrition on immunologic function of patients with cerebral hemorrhage

目的分析早期肠内营养对脑出血患者免疫功能的影响。方法 2014年5月～2017年1月从河南省沁阳市中医院抽取66例脑出血患者,随机分组后实施不同疗法:观察组33例实施肠内营养,对照组33例实施完全肠外营养,统计患者的免疫功能、并发症。结果治疗第2天、第14天观察组的神经功能评分分别为(31.62±7.89)分和(24.96±5.27)分,对照组分别为(28.04±6.12)分和(18.24±5.60)分,组间比较差异有统计学意义(P<0.05)。治疗前两组Ig A、Ig G、Ig M、LYM差异无统计学意义(P>0.05);治疗第2天,两组之间除LYM有统计学意义(P<0.01)外,其他指标比较差异无统计学意义;治疗第14天观察组的免疫指标明显高于对照组,差异有统计学意义(P<0.01)。观察组患者的肺部感染、心功能衰竭等并发症发生率为9.1%(3/33),明显低于对照组的30.3%(10/33),组间比较差异有统计学意义(P<0.05)。结论脑出血患者早期给予肠内营养作用突出,能恢复免疫功能,预防并发症,增强疗效,值得借鉴。

Objective To investigate the influence of early enteral nutrition on immunologic function of patients with cerebral hemorrhage.Methods 66 cases with cerebral hemorrhage in our hospital from May 2014 to January 2017 were selected and given different therapies after random grouping.33 cases in observation group given enteral nutrition,while 33 cases in control group were given complete parenteral nutrition.And then,the immune function and complications of the patients were counted.Results On the 2nd and 14th day after treatment,the neurological function scores of the observation group were(31.62±7.89)and(24.96±5.27)respectively,and those of the control group were(28.04±6.12)and(18.24±5.60),respectively,difference was statistically significant(P<0.05).Before treatment,difference in IgA,IgG,IgM and LYM between the two groups was not statistically significant(P>0.05);on the 2nd day after treatment,there was no statistically significant difference in other indexes except LYM between the two groups(P<0.01);on the 14th day after treatment,immunological indexes in the observation group were significantly higher than those in the control group,difference was statistically significant(P<0.01).The incidence of pulmonary infection and heart failure in the observation group was 9.1%(3/33),which was significantly lower than that in the control group(30.3%,10/33),difference was statistically significant(P<0.05).Conclusion Early enteral nutrition has significant effect on cerebral hemorrhage patients,it can recover immunologic function,prevent complications,and improve curative effect,which is worthy of reference.