免疫细胞与肝细胞癌关系的研究进展

Research progress of relationship the between immune cells and hepatocellular carcinoma

肝细胞癌(HCC)是肝脏的原发恶性肿瘤,有较高的发病率和死亡率。免疫系统功能紊乱可以导致机体对HCC免疫监视的异常,同时肝癌细胞也会作用于机体免疫系统,发生免疫逃逸。包括树突状细胞(DCs)、巨噬细胞(MΦ)、髓源性抑制性细胞(MDSCs)、自然杀伤细胞(NK)、细胞毒性T淋巴细胞(CTL)、CD4+T细胞、调节性T细胞(Treg)、辅助性T细胞7(Th7)和自然杀伤T细胞(NKT)在内的多种免疫细胞均参与HCC的发生和发展进程,本文对免疫细胞与肝癌相互作用关系的研究进展进行系统综述,以期为HCC的治疗提供新的思路和方法。

Hepatocellular carcinoma(HCC) is the primary malignant tumor of liver, which has a high morbidity and mortality. Dysfunction of the immune system can lead to abnormal immune surveillance of HCC, and hepatocellular carcinoma cells can also act on the immune system to lead immune escape. Immune cells including dendritic cells(DCs), macrophage(MΦ), myeloid-derived suppressor cells(MDSCs), natural killer cell(NK), cytotoxic lymphocyte(CTL), CD4+T cell, regulatory cells(Treg), helper T cell 7(Th7) and natural killer T cells(NKT), play an important role in the occurrence and development process of HCC. In this paper, advances in the interaction between immune cells and liver cancer are reviewed to provide new ideas and methods for the treatment of HCC.