脐血食欲素、脂联素与新生儿生长发育的相关性

Relationship of cord blood orexin and adiponectin and growth and development of neonatal

目的研究脐血食欲素、脂联素与新生儿生长发育的相关性。方法选取2015年10月～2016年2月于河北医科大学第一医院出生的90例新生儿作为研究对象,分为早产儿组(30例)和足月儿组(60例)。分别测定脐血食欲素、脂联素水平,精确测量生后第1天体重、身长、头围,并计算体重指数(BMI)和Ponderal指数(PI),分析脐血食欲素、脂联素水平与新生儿生长发育指标的相关性。结果两组新生儿在胎龄、体重、身长、头围、胎盘重量和BMI等比较,差异有高度统计学意义(P <0.01);在性别和PI等比较,差异无统计学意义(P> 0.05)。早产儿脐血食欲素水平显著高于足月儿,而脂联素水平明显低于足月儿,差异有统计学意义(P <0.01)。食欲素与其胎龄、体重、身长、头围、胎盘重量和BMI呈负相关(r=-0.612、-0.562、-0.582、-0.557、-0.608、-0.521,P <0.05),脂联素与其胎龄、体重、身长、头围、胎盘重量和BMI呈正相关(r=0.547、0.534、0.512、0.524、0.533、0.498,P <0.05),食欲素、脂联素与性别和PI无相关性(P> 0.05)。进一步多元逐步回归分析显示新生儿脐血食欲素、脂联素与新生儿生长发育指标密切相关(P <0.05)。结论脐血食欲素、脂联素参与新生儿的体质量调节和生长发育过程,与新生儿生长发育指标密切相关,在一定程度上可以反映新生儿生长发育情况。

Objective To study the relationship of the cord blood orexin, adiponectin, growth and development of neonatal. Methods From October 2015 to February 2016, in the First Hospital of Hebei Medical University, 90 newborns were selected as study object, they were divided into preterm group(30 cases) and term infant group(60 cases).The levels of cord blood orexin and adiponectin were measured, and the body weight, body length and head circumference were accurate measured at the first days after birth, and the body mass index(BMI) and Ponderal index(PI) were calculated. The correlation of the levels cord blood orexin and adiponectin and newborn growth indexes were analyzed.Results The gestational age, body weight, body height, head circumference, placental weight and BMI in two groups were compared, the differences were statistically significant(P < 0.01); the gender and PI were compared, the differences were not statistically significant(P > 0.05). The level of cord blood orexin in preterm group was significantly higher than the term infants group, and the level of adiponectin in preterm group was significantly lower than the term infants group, the differences were statistically significant(P < 0.01). The level of orexin was negative correlation to gestational age, body weight, body height, head circumference, placental weight and BMI(r =-0.612,-0.562,-0.582,-0.557,-0.608,-0.521, all P < 0.05), and the level of adiponectin was positive correlation to gestational age, body weight, body height, head circumference, placental weight and BMI(r = 0.547, 0.534, 0.512, 0.524, 0.533, 0.498, all P <0.05), but the level of orexin and adiponectin were not correlation to gender and PI(P > 0.05). Further multiple stepwise regression analysis showed that cord blood orexin and adiponectin were closely related to neonatal growth and development indicators(P < 0.05). Conclusion Orexin and adiponectin in cord blood are involved in the body weight reg-ulation and growth process of newborns, and they are closely related to the growth and development indicators of newborns, they may reflect the growth and development of newborn.